20.500.12556/RUP-22184 Polyphenolic composition, genetic profile and in vitro antioxidant and cytotoxic activities of artichoke varieties “Strunjanska articoka”, “Romanesco” and "Violetto di Romagna" In recent years, artichokes have gained attention as functional foods due to their polyphenol content and health benefits. While Italian varieties have been widely studied, the Slovenian landrace “Strunjanska articoka” remains largely unexplored. This study compared “Strunjanska articoka” with two Italian varieties, “Romanesco” and “Violetto di Romagna”, assessing genetic profiles, chemical composition, antioxidant activity, and effects on lipid accumulation. The genetic analysis confirmed the uniqueness and clear differentiation of the landrace “Strunjanska articoka” from the two commercial varieties. Analysing the profiles of phenolic compounds in the leaf extracts of these morphologically different artichoke varieties underlines their unique phytochemical composition, which translates into different health benefits. “Romanesco” showed the highest free radical scavenging activity (EC50 = 100 µg/mL), followed by “Strunjanska articoka” (EC50 = 143 µg/mL), and “Violetto di Romagna” (EC50 = 160 µg/mL). Importantly, “Strunjanska articoka” demonstrated superior cytoprotective effects against oxidative stress in HepG2 and CCD112CoN cells. It also reduced lipid accumulation in HepG2 cells, along with “Violetto di Romagna,” whereas “Romanesco” did not. These findings justify further investigation into the potential therapeutic effects of “Strunjanska articoka” and support the rationale for its cultivation. https://repozitorij.upr.si/admin/GradivoDatoteke.php?id=22184 artichoke leaf extracts phenolic compounds antioxidative potential lipid accumulation ekstrakti listov artičoke fenolne spojine antioksidativni potencial kopičenje maščob true false true Angleški jezik Slovenski jezik Članek v reviji 2025-12-06 00:08:37 2025-12-06 00:08:38 2025-12-07 03:03:33 0000-00-00 00:00:00 2025 0 0 str. [article no.] 42347 Vol. 15 2025 0000-00-00 PostprintKoncna Objavljeno apc 0000-00-00 0000-00-00 2025-11-27 613.2 2045-2322 10.1038/s41598-025-26443-w 260279043 https://www.nature.com/articles/s41598-025-26443-w 1 9dceaa61-d22f-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32196 https://doi.org/10.1038/s41598-025-26443-w 1 9f3c2b27-d22f-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32197 RAZ_Kramberger_Katja_2025.pdf RAZ_Kramberger_Katja_2025.pdf 1 72BD9C38D9F10ABE9C118CD063EF5665 264c63ce7ce46da19b994f52a2d4229fa8dfd1de66a63a7f21de0d213aaf6a46 ceeba8f4-d22f-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32198 Fakulteta za vede o zdravju 0 0 0