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292. Effect of ionizing radiation on human skeletal muscle precursor cellsMihaela Jurdana, Maja Čemažar, Katarina Pegan, Tomaž Marš, 2013, published scientific conference contribution Abstract: Background. Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures.Materials and methods. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin - 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death.Results. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70).Conclusions. Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions.
Keywords: myoblasts, irradiation, proliferation, interleukin 6, muscle regeneration, apoptosis
Published in RUP: 30.12.2015; Views: 4058; Downloads: 150
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293. Zdravstvena pismenost : stanje koncepta in nadaljnji razvoj z vključevanjem zdravstvene negeKatarina Babnik, Tamara Štemberger Kolnik, Anita Bratuž, 2013, review article Abstract: Uvod: Koncept zdravstvene pismenosti v zadnjem desetletju doživlja intenziven razvoj. Namen prispevka je predstaviti pregled razvoja koncepta zdravstvene pismenosti, inštrumentov za merjenje, modelov, ki pojasnjujejo determinante, in posledice zdravstvene pismenosti ter vlogo zdravstvene nege v nadaljnjem razvoju koncepta. Metode: Pregled literature je bil izveden z deskriptivno metodo. Iskanje del je potekalo v obdobju od januarja 2012 do avgusta 2012 s pomočjo baz podatkov: PubMed, Medline, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Health Source: Nursing/Academic Edition, Academic Search Complete, COBIB.SI in z brskalnikom Google. Za iskanje literature smo uporabili naslednje pojme: i) health AND literacy, ii) health AND literacy AND assessment, iii) health AND literacy AND definitions, iv) health AND literacy AND models, v) health AND literacy AND nursing, pri čemer je v bazi COBIB.SI iskanje potekalo tudi z ustreznimi slovenskimi izrazi. Izpis zadetkov je bil v znanstvenih bazah omejen z zahtevami: znanstvene revije, recenzirani članki in celotno besedilo. V prvem koraku je bilo tako dobljeno 11.579 del. V drugem koraku smo z dodatnimi kriteriji iskanja del, povezanimi s cilji kvalitativnega pregleda, pridobili 100 znanstvenih del, ki opisujejo in razlagajo koncept zdravstvene pismenosti. Rezultati: Zdravstvena pismenost se je skozi čas razvijala v smeri od pretežno medicinskega koncepta k javnozdravstvenemu in zdravstvenovzgojnemu konceptu. Številni merski pripomočki in teoretični modeli še ne dajo zadovoljivih odgovorov na vprašanje, kako zdravstvena pismenost posameznika vpliva na sistemske in splošne družbene vidike, kot so zdravstvu namenjeni stroški, kakovost zdravstvenih storitev in splošni zdravstveni izidi. Diskusija in zaključek: Zdravstvenovzgojno delo mora temeljiti na oceni zdravstvene pismenosti posameznikov in skupin. Tudi v Sloveniji je potrebno razviti presejalni inštrument, s pomočjo katerega bo mogoče identificirati rizične skupine in načrtovati intervencijske zdravstvenovzgojne programe za povečanje zdravstvene pismenosti.
Keywords: zdravstvena pismenost, presejalni instrumenti, modeli, zdravstvena nega
Published in RUP: 30.12.2015; Views: 6211; Downloads: 121
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300. Analiza študijskih programov Fakultete za turistične študije - Turistice Univerze na Primorskem : triangulacija stališč in mnenj deležnikovJanez Mekinc, Gorazd Sedmak, Katarina Mušič, Gordana Ivankovič, 2015, independent scientific component part or a chapter in a monograph Keywords: kakovost, turizem, visokošolski študijski programi, Univerza na Primorskem, Fakulteta za turistične študije Turistica, evalvacija
Published in RUP: 15.10.2015; Views: 3725; Downloads: 89
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