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2. Načrtovanje matematičnih dejavnosti : diplomska nalogaKatarina Tratar, 2020, undergraduate thesis Keywords: matematika, načrtovanje, matematična področja, prikriti kurikulum, matematične dejavnosti, mathematics, planning, mathematical fields, covert curriculum, mathematical activities
Published in RUP: 22.07.2020; Views: 1550; Downloads: 106
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3. Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectivenessMaja Čemažar, Vesna Todorović, Janez Ščančar, Urša Lampreht Tratar, Monika Savarin, Urška Kamenšek, Simona Kranjc Brezar, Andrej Cör, Gregor Serša, 2015, original scientific article Abstract: Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most suitable for clinical use. Intravenous administration of cisplatin for electrochemotherapy is still not widely accepted in the clinics, presumably due to its lower antitumor effectiveness, but adjuvant therapy by immunomodulatory or vascular-targeting agents could provide a way for its potentiation. Hence, the aim of the present study was to explore the possibility of adjuvant tumour necrosis factor % (TNF-%) therapy to potentiate antitumor effectiveness of electrochemotherapy with intravenous cisplatin administration in murine sarcoma. Materials and methods. In vivo study was designed to evaluate the effect of TNF-% applied before or after the electrochemotherapy and to evaluate the effect of adjuvant TNF-% on electrochemotherapy with different cisplatin doses. Results. A synergistic interaction between TNF-% and electrochemotherapy was observed. Administration of TNF-% before the electrochemotherapy resulted in longer tumour growth delay and increased tumour curability, and was significantly more effective than TNF-% administration after the electrochemotherapy. Tumour analysis revealed increased platinum content in tumours, TNF-% induced blood vessel damage and increased tumour necrosis after combination of TNF-% and electrochemotherapy, indicating an anti-vascular action of TNF-%. In addition, immunomodulatory effect might have contributed to curability rate of the tumours. Conclusion. Adjuvant intratumoural TNF-% therapy synergistically contributes to electrochemotherapy with intravenous cisplatin administration. Due to its potentiation at all doses of cisplatin, the combined treatment is predicted to be effective also in tumours, where the drug concentration is suboptimal or in bigger tumours, where electrochemotherapy with intravenous cisplatin is not expected to be sufficiently effective.
Keywords: electrochemotherapy, TNF, adjuvant immunotherapy, cisplatin
Published in RUP: 09.08.2016; Views: 5687; Downloads: 135
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4. Endoglin (CD105) silencing mediated by shRNA under the control of Endothelin-1 promoter for targeted gene therapy of MelanomaNataša Tešić, Urška Kamenšek, Gregor Serša, Simona Kranjc Brezar, Monika Savarin, Urša Lampreht Tratar, Véronique Préat, Gaëlle Vandermeulen, Miha Butinar, Boris Turk, Maja Čemažar, 2015, original scientific article Abstract: Endoglin (CD105), a transforming growth factor (TGF)-% coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a eukaryotic expression plasmid encoding the shRNA molecules against CD105 under the control of endothelin-1 promoter and to evaluate its therapeutic potential both in vitro in murine B16F10-luc melanoma and SVEC4-10 endothelial cells and in vivo in mice bearing highly metastatic B16F10-luc tumors. Plasmid encoding shRNA against CD105 under the control of the constitutive U6 promoter was used as a control. We demonstrated the antiproliferative and antiangiogenic effects of both plasmids in SVEC4-10 cells, as well as a moderate antitumor and pronounced antimetastatic effect in B16F10-luc tumors in vivo. Our results provide evidence that targeting melanoma with shRNA molecules against CD105 under the control of endothelin-1 promoter is a feasible and effective treatment, especially for the reduction of metastatic spread.
Keywords: melanoma, electroporation, endoglin (CD105), endothelin-1, gene therapy
Published in RUP: 14.10.2015; Views: 3767; Downloads: 131
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5. Pomen organizacijske kulture za uspešnost storitvenih organizacijNataša Vrčon-Tratar, Boris Snoj, 2002, original scientific article Abstract: Nedvomno je organizacijska kultura kot notranja zavest determinanta vedenja zaposlenih in pomemben fenomen znanstvenega proučevanja, predvsem z vidika potencialnega dejavnika razvijana konkurenčne prednosti organizacij. V prispevku obravnavamo nekatere vidike kulture organizacije in ugotavljamo, ali ustrezna usmerjenost in moč organizacijske kulture pomembno prispevata k učinkovitemu uresničevanju ciljev v organizacijah ter doseganju večje poslovne uspešnosti. Posebej osvetljujemo pomen organizacijske kulture v storitvenih organizacijah, v katerih je človeški dejavnik zaradi narave storitev ključni tvorec t. i. "mehkih sestavin" ponudbe, ki dandanes vse bolj pomenijo neizčrpen vir konkurenčnega pozicioniranja na trgu.
Keywords: marketing, trženje, organizacijska kultura, organizacija, kultura, storitve, uspešnost, uspešnost poslovanja, poslovanje, poslovanje podjetja, podjetje
Published in RUP: 10.07.2015; Views: 3401; Downloads: 49
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7. Spremljanje zadovoljstva odjemalcev v prodajalnah s čevljiIris Rebek, 2005, undergraduate thesis Keywords: trgovina, prodaja, čevlji, odjemalec, kontaktne osebe, zadovoljstvo odjemalcev, storitve, kakovost storitev, navidezni nakup, diplomska dela
Published in RUP: 15.10.2013; Views: 3113; Downloads: 163
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8. Pomen organizacijske kulture za kakovost izvajanja storitev v bančnih ustanovahNataša Vrčon-Tratar, Boris Snoj, 2002, published professional conference contribution Abstract: Nedvomno je organizacijska kultura kot notranja zavest in determinanta vedenja zaposlenih pomemben fenomen znanstvenega proučevanja predvsem z vidika potencialnega dejavnika razvijanja konkurenčne prednosti organizacij. V prispevku obravnavamo nekatere vidike kulture organizacije ter ugotavljamo, kako in ali lahko ustrezne temeljne vrednote v okviru te prispevajo k učinkovitemu uresničevanju ciljev v organizacijah. Posebej osvetljujemo temeljno sestavino marketinškega koncepta - naravnanost k odjemalcem - kot možno razsežnost organizacijske kulture ter zvezo med usmerjenostjo organizacijske kulture, kakovostjo storitev in uspešnostjo poslovanja podjetja. Zanima nas, ali usklajenost v zvezi s tem načelom na različnih ravneh organizacije (moč kulture) vpliva na zadovoljstvo zaposlenih in s tem na kakovost storitev in zadovoljstvo odjemalcev.
Keywords: organizacijska kultura, banke, finančne ustanove, kvaliteta, storitve, bančništvo
Published in RUP: 15.10.2013; Views: 3880; Downloads: 112
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