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1.
Analiza avtomobilskih zavarovanj
Nataša Čebašek, 2011, undergraduate thesis

Found in: osebi
Keywords: zavarovalnica, zavarovalne police, zavarovalne premije, elektronsko poslovanje, Slovenija
Published: 15.10.2013; Views: 1985; Downloads: 65
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Endoglin (CD105) silencing mediated by shRNA under the control of Endothelin-1 promoter for targeted gene therapy of Melanoma
Simona Kranjc, Boris Turk, Nataša Tešić, Maja Čemažar, Véronique Préat, Gregor Serša, Urška Kamenšek, Monika Štimac, Urša Lampreht Tratar, Gaëlle Vandermeulen, Miha Butinar, 2015, original scientific article

Abstract: Endoglin (CD105), a transforming growth factor (TGF)-% coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a eukaryotic expression plasmid encoding the shRNA molecules against CD105 under the control of endothelin-1 promoter and to evaluate its therapeutic potential both in vitro in murine B16F10-luc melanoma and SVEC4-10 endothelial cells and in vivo in mice bearing highly metastatic B16F10-luc tumors. Plasmid encoding shRNA against CD105 under the control of the constitutive U6 promoter was used as a control. We demonstrated the antiproliferative and antiangiogenic effects of both plasmids in SVEC4-10 cells, as well as a moderate antitumor and pronounced antimetastatic effect in B16F10-luc tumors in vivo. Our results provide evidence that targeting melanoma with shRNA molecules against CD105 under the control of endothelin-1 promoter is a feasible and effective treatment, especially for the reduction of metastatic spread.
Found in: osebi
Keywords: melanoma, electroporation, endoglin (CD105), endothelin-1, gene therapy
Published: 14.10.2015; Views: 1699; Downloads: 72
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4.
Vzgoja in motivacija mladega bralca
Nataša Požar Barut, 2013, undergraduate thesis

Found in: osebi
Keywords: branje, bralna vzgoja, mladi bralci, bralna motivacija, notranja motivacija, zunanja motivacija, opismenjevanje, italijanščina, diplomska dela
Published: 15.10.2013; Views: 1692; Downloads: 25
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5.
Meje človeških zmogljivosti na primeru slovenske ekstremistke in ekstremistov
Nataša Tretjak, 2010, undergraduate thesis

Found in: osebi
Keywords: ekstremni športi, ekstremni športniki, podvig, osebnost, motivacija, izziv, tveganje, smisel, način življenja, diplomska dela
Published: 15.10.2013; Views: 2125; Downloads: 36
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Poplave morja na slovenski obali
Nataša Kolega, 2005, undergraduate thesis

Found in: osebi
Keywords: poplave morja, plimovanje, slovenska obala, karte poplavnih območij, GIS, geografija, diplomska dela
Published: 15.10.2013; Views: 2458; Downloads: 67
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Slovenian coast sea floods risk
Nataša Kolega, 2006, original scientific article

Found in: osebi
Keywords: geografija, morje, poplave morja, poplavna območja, ogroženost, obala, Slovenija
Published: 15.10.2013; Views: 1669; Downloads: 23
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Medsebojno vplivanje kopnega in morja
Nataša Kolega, 2009, doctoral dissertation

Found in: osebi
Keywords: geografija, geografski informacijski sistemi, obalni pas, kopno, morje, stik med kopnim in morjem, obalna linija, sonar, lidar, digitalni model reliefa, doktorske disertacije
Published: 15.10.2013; Views: 2684; Downloads: 89
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