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1.
New onset of constipation during long-term physical inactivity
Paola Iovino, Giuseppe Chiarioni, Giancarlo Bilancio, Massimo Cirillo, Igor B. Mekjavić, Rado Pišot, Carolina Ciacci, 2013, original scientific article

Found in: ključnih besedah
Summary of found: ...physical inactivity, bowel function, constipation, bed rest, ...
Keywords: physical inactivity, bowel function, constipation, bed rest
Published: 15.10.2013; Views: 2777; Downloads: 24
URL Full text (0,00 KB)

2.
Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach
Francesco Agostini, Luciano Dalla Libera, Joern Rittweger, Sara Mazzucco, Mihaela Jurdana, Igor B. Mekjavić, Rado Pišot, Luisa Gorza, Marco Narici, Gianni Biolo, 2010, original scientific article

Abstract: Oxidative stress is often associated to inactivity-mediated skeletal muscle atrophy. Glutathione is one of the major antioxidant system stimulated, both at muscular and systemic level, by activation of oxidative processes. We measured changes in glutathione availability, oxidative stress induction and atrophy extent mediated by 35-days of experimental bed rest in vastus lateralis muscle of healthy human volunteers. To assess muscle glutathione synthesis, we applied a novel single-biopsy and double-tracer ([2H2]glycine and [15N]glycine) approach based on evaluation of steady-state precursor incorporation in product. The correlations between the traditional (multiple-samples, one-tracer) and new (one-sample, double-tracer infusion) methods were analyzed in erythrocytes by Passing & Bablok and Altman-Bland tests. Muscle glutathione absolute synthesis rate increased following bed rest from 5.5 1.1 to 11.0 1.5 mmol (kg wet tissue / day)-1 (n=9; p=0.02) while glutathione concentration failed to change significantly. Bed rest induced vastus lateralis muscle atrophy, as assessed by pennation angle changes measured by ultrasonography (from 18.6 1.0 to 15.3 0.9 degrees; p=0.01) and thickness changes (from 2.3 0.2 to 1.9 0.1 cm; p<0.001). Moreover, bed rest increased protein oxidative stress, as measured by muscle protein carbonylation changes (from 0.6 0.1 to 1.00 0.1 Oxy RP-1; p<0.04). In conclusion, we developed in erythrocytes a new minimally-invasive method to determine peptide synthesis rate in human tissues. Application of the new method to skeletal muscle suggests that disuse atrophy is associated to oxidative stress induction as well as to compensatory activation of the glutathione system
Found in: ključnih besedah
Summary of found: ...extent mediated by 35-days of experimental bed rest in vastus lateralis muscle of healthy human...
Keywords: Antioxidant system, Muscle damage, Oxidative stress, bed rest, muscle glutathione, stable isotopes
Published: 15.10.2013; Views: 2126; Downloads: 85
URL Full text (0,00 KB)

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Whole muscle contractile parameters and thickness loss during 35-day bed rest
Rado Pišot, Marco Narici, Boštjan Šimunič, Maarten D. de Boer, Olivier Seynnes, Mihaela Jurdana, Gianni Biolo, Igor B. Mekjavić, 2008, original scientific article

Abstract: Extended exposure to microgravity leads to significant musculoskeletal adaptations. Contractile parameters of four skeletal muscles (biceps brachii-BB, vastus medialis-VM, biceps femoris-BF and gastrocnemius medialis-GM) were measured in ten healthy males (aged 22.3 +/- 2.2 years) during 35 days of horizontal bed rest by a mechanomyography-based method termed 'tensiomyography' (TMG). Two contractile parameters: contraction time (Tc) and maximal displacement (Dm) were individually measured from electrically evoked maximal single twitch TMG response of all four muscles before and after bed rest. Significant changes in Tc were found after bed rest, as shown by an increase in GM muscle Tc by 18% (p < 0.01). Dm values significantly increased (p < 0.01) after bed rest, by 24, 26 and 30% in the VM, BF and GM muscles, respectively. In the GM, the change in Dm significantly correlated with the decrease in muscle thickness (r = -0.70, p < 0.01). In conclusion, bed rest induced changes in both Dm and Tc of the TMG signal; changes in Dm being inversely related to those of muscle thickness. Amongst the investigated muscles, most affected, in terms of atrophy and mechanical alterations, were those of the lower limbs. The observed increase in Dm may be attributed to a decrease in muscle, as well as tendon stiffness, causing larger muscle fibre and non-contractile tissue oscillations following contraction.
Found in: ključnih besedah
Keywords: Bed rest, skeletal muscle, muscle contraction, muscle thickness, mechanomyography, tensiomiography, ultrasound
Published: 15.10.2013; Views: 2268; Downloads: 76
URL Full text (0,00 KB)
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5.
Effects of long-term physical inactivity on depressive symptoms, anxiety, and coping behaviour of young participants
Petra Dolenc, Rado Pišot, 2011, original scientific article

Found in: ključnih besedah
Summary of found: ...physical inactivity, mental health, bed rest, ...
Keywords: physical inactivity, mental health, bed rest
Published: 15.10.2013; Views: 3070; Downloads: 27
URL Full text (0,00 KB)

6.
Costamere remodeling with muscle loading and unloading in healthy young men
Ruowei Li, Marco V. Narici, Robert M. Erskine, Olivier Seynnes, Joern Rittweger, Rado Pišot, Boštjan Šimunič, M. Flück, 2013, original scientific article

Found in: ključnih besedah
Summary of found: ...focal adhesion kinase, hypertrophy, physical inactivity, bed rest, skeletal muscle, myofibril, vinculin, ...
Keywords: costamere, atrophy, focal adhesion kinase, hypertrophy, physical inactivity, bed rest, skeletal muscle, myofibril, vinculin
Published: 15.10.2013; Views: 1889; Downloads: 79
URL Full text (0,00 KB)

7.
Psihološki učinki skrajne gibalne neaktivnosti v pogojih simulirane breztežnosti
Tjaša Dimec Časar, Petra Dolenc, Rado Pišot, Matej Tušak, 2009, original scientific article

Abstract: Najpogostejša metoda za spremljanje učinkov popolne gibalne neaktivnosti na človekov organizem je simuliranje breztežnostnega stanja oziroma bed rest (BR) model, ki predpostavlja daljše obdobje ležanja v vodoravnem položaju. V raziskavi smo ugotavljali spremembe v razpoloženju, psihološkem blagostanju, spoprijemalnih strategijah in telesni samopodobi med 35-dnevnim mirovanjem v strogem vodoravnem položaju pri desetih mladih zdravih moških. Psihološke vprašalnike so izpolnjevali pred začetkom eksperimenta in ob koncu le-tega. Emocionalna stanja, zadovoljstvo z življenjem in telesna samopodoba se niso statistično pomembno spremenili po BR obdobju, rezultati na lestvici CRI pa kažejo na trend porasta uporabe na emocije usmerjenega spoprijemanja in upada na problem usmerjenega soočanja s težavami. Splošno počutje udeležencev, izraženo z rezultatom na lestvici GHQ, se je po eksperimentu v primerjavi s predeksperimentalnim obdobjem poslabšalo. Izraženost teh simptomov pa je bila tudi po obdobju gibalne imobiliziranosti relativno nizka in ni predstavljala grožnje za psihično zdravje udeležencev. Naši rezultati kažejo na to, da so ugodne bivanjske razmere in možnost socialne interakcije v času popolne telesne neaktivnosti nekakšno varovalo pred poslabšanjem psihičnega statusa oziroma ublažijo negativne učinke, ki jih povzroča daljša gibalna imobiliziranost. Dobljeni izsledki imajo aplikativno vrednost na področju zdravstvene preventive in rehabilitacije.
Found in: ključnih besedah
Summary of found: ...organizem je simuliranje breztežnostnega stanja oziroma bed rest (BR) model, ki predpostavlja daljše obdobje ležanja...
Keywords: gibalna neaktivnost, psihično stanje, simulirana breztežnost, bed rest raziskave
Published: 10.07.2015; Views: 1832; Downloads: 16
URL Full text (0,00 KB)

8.
Ugotavljanje učinka dolgotrajne gibalne neaktivnosti na spominske funkcije pri zdravih odraslih moških
Julija Podbevšek, 2014, undergraduate thesis

Found in: ključnih besedah
Summary of found: ...gibalna neaktivnost, bed rest raziskave, kognivitno delovanje, spomin, ...
Keywords: gibalna neaktivnost, bed rest raziskave, kognivitno delovanje, spomin
Published: 10.07.2015; Views: 1447; Downloads: 4
URL Full text (0,00 KB)

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