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Between-day reliability of a method for non-invasive estimation of muscle composition
Boštjan Šimunič, 2012, original scientific article

Found in: ključnih besedah
Summary of found: ... Skeletal muscle, Tensiomyography, repeatability, validity, ...
Keywords: Skeletal muscle, Tensiomyography, repeatability, validity
Published: 15.10.2013; Views: 2034; Downloads: 84
URL Full text (0,00 KB)

Neural agrin changes the electrical properties of developing human skeletal muscle cells
Mihaela Jurdana, Guido Fumagalli, Zoran Grubič, Paola Lorenzon, Tomaž Marš, Marina Sciancalepore, 2009, original scientific article

Abstract: Recent investigations suggest that the effects of neural agrin might not be limited to neuromuscular junction formation and maintenance and that other aspects of muscle development might be promoted by agrin. Here we tested the hypothesis that agrin induces a change in the excitability properties in primary cultures of non-innervated human myotubes. Electrical membrane properties of human myotubes were recorded using the whole-cell patch-clamp technique. Cell incubation with recombinant chick neural agrin (1 nM) led to amore negative membrane resting potential. Addition of strophanthidin, a blocker of the Na(+)žK(+) ATPase, depolarized agrin-treated myotubes stronger than control, indicating, in the presence of agrin, a higher contribution of the Na(+)žK(+) ATPase in establishing the resting membrane potential. Indeed, larger amounts of both the alpha1 and the alpha2 isoforms of the Na(+)žK(+) ATPase protein were expressed in agrin-treated cells. A slight but significantdown-regulation of functional apamin-sensitive K(+) channels was observed after agrin treatment. These results indicate that neural agrin mightact as a trophic factor promoting the maturation of membrane electrical properties during differentiation, confirming the role of agrin as a general promoter of muscle development.
Found in: ključnih besedah
Keywords: agrin, myogenesis, electrical membrane properties, skeletal muscle, Na+/K+ pump
Published: 15.10.2013; Views: 1610; Downloads: 75
URL Full text (0,00 KB)
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Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training
Desy Salvadego, R. Domenis, Stefano Lazzer, Simone Porcelli, Joern Rittweger, Giovanna Rizzo, I. Mavelli, Boštjan Šimunič, Rado Pišot, Bruno Grassi, 2013, original scientific article

Abstract: Oxidative function during exercise was evaluated in 11 young athletes with marked skeletal muscle hypertrophy induced by long-term resistance training (RTA, body mass 102.67.3 kg, meanSD) and 11 controls (CTRL, body mass 77.86.0). Pulmonary O2 uptake (V'O2) and vastus lateralis muscle fractional O2 extraction (by near-infrared spectroscopy) were determined during an incremental cycle ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers obtained by biopsy. Quadriceps femoris muscle cross sectional area, volume (determined by magnetic resonance imaging) and strength were greater in RTA vs. CTRL (by ~40%, ~33% and ~20%, respectively). V'O2peak during CE was higher in RTA vs. CTRL (4.050.64 L min-1 vs. 3.560.30); no difference between groups was observed during KE. The O2 cost of CE exercise was not different between groups. When divided per muscle mass (for CE) or quadriceps muscle mass (for KE) V'O2peak was lower (by 15-20%) in RTA vs. CTRL. Vastus lateralis fractional O2 extraction was lower in RTA vs. CTRL at all work rates, both during CE and KE. RTA had higher ADP-stimulated mitochondrial respiration (56.723.7 pmolO2s-1mg-1 ww) vs. CTRL (35.710.2), and a tighter coupling of oxidative phosphorylation. In RTA the greater muscle mass and maximal force, and the enhanced mitochondrial respiration seem to compensate for the hypertrophy-induced impaired peripheral O2 diffusion. The net results are an enhanced whole body oxidative function at peak exercise, and unchanged efficiency and O2 cost at submaximal exercise, despite a much greater body mass
Found in: ključnih besedah
Keywords: skeletal muscle, hypertrophy, mitochondrial respiration, oxidative metabolism, exercise
Published: 15.10.2013; Views: 2048; Downloads: 57
URL Full text (0,00 KB)

Whole muscle contractile parameters and thickness loss during 35-day bed rest
Rado Pišot, Marco Narici, Boštjan Šimunič, Maarten D. de Boer, Olivier Seynnes, Mihaela Jurdana, Gianni Biolo, Igor B. Mekjavić, 2008, original scientific article

Abstract: Extended exposure to microgravity leads to significant musculoskeletal adaptations. Contractile parameters of four skeletal muscles (biceps brachii-BB, vastus medialis-VM, biceps femoris-BF and gastrocnemius medialis-GM) were measured in ten healthy males (aged 22.3 +/- 2.2 years) during 35 days of horizontal bed rest by a mechanomyography-based method termed 'tensiomyography' (TMG). Two contractile parameters: contraction time (Tc) and maximal displacement (Dm) were individually measured from electrically evoked maximal single twitch TMG response of all four muscles before and after bed rest. Significant changes in Tc were found after bed rest, as shown by an increase in GM muscle Tc by 18% (p < 0.01). Dm values significantly increased (p < 0.01) after bed rest, by 24, 26 and 30% in the VM, BF and GM muscles, respectively. In the GM, the change in Dm significantly correlated with the decrease in muscle thickness (r = -0.70, p < 0.01). In conclusion, bed rest induced changes in both Dm and Tc of the TMG signal; changes in Dm being inversely related to those of muscle thickness. Amongst the investigated muscles, most affected, in terms of atrophy and mechanical alterations, were those of the lower limbs. The observed increase in Dm may be attributed to a decrease in muscle, as well as tendon stiffness, causing larger muscle fibre and non-contractile tissue oscillations following contraction.
Found in: ključnih besedah
Summary of found: ...Extended exposure to microgravity leads to significant musculo skeletal adaptations. Contractile parameters of four skeletal muscles...
Keywords: Bed rest, skeletal muscle, muscle contraction, muscle thickness, mechanomyography, tensiomiography, ultrasound
Published: 15.10.2013; Views: 2213; Downloads: 68
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Costamere remodeling with muscle loading and unloading in healthy young men
Ruowei Li, Marco V. Narici, Robert M. Erskine, Olivier Seynnes, Joern Rittweger, Rado Pišot, Boštjan Šimunič, M. Flück, 2013, original scientific article

Found in: ključnih besedah
Summary of found: ...adhesion kinase, hypertrophy, physical inactivity, bed rest, skeletal muscle, myofibril, vinculin, ...
Keywords: costamere, atrophy, focal adhesion kinase, hypertrophy, physical inactivity, bed rest, skeletal muscle, myofibril, vinculin
Published: 15.10.2013; Views: 1839; Downloads: 71
URL Full text (0,00 KB)

Increased fatigability of the gastrocnemius medialis muscle in individuals with intermittent claudication
Mladen Gasparini, Mišo Šabovič, Igor D. Gregoric, Boštjan Šimunič, Rado Pišot, 2012, original scientific article

Found in: ključnih besedah
Summary of found: ...Peripheral arterial disease, Intermittent claudication, Skeletal muscle, Fatigue, ...
Keywords: Peripheral arterial disease, Intermittent claudication, Skeletal muscle, Fatigue
Published: 15.10.2013; Views: 1616; Downloads: 69
URL Full text (0,00 KB)

Single muscle fibre contractile properties differ between body-builders, power athletes and control subjects
J. P. Meijer, R. T. Jaspers, Joern Rittweger, Olivier Seynnes, S. Kamandulis, M. Brazaitis, A. Skurvydas, Rado Pišot, Boštjan Šimunič, Marco Narici, H. Degens, 2015, original scientific article

Found in: ključnih besedah
Summary of found: ... skeletal muscles, muscle fibers, contractile properties, body-builders, power...
Keywords: skeletal muscles, muscle fibers, contractile properties, body-builders, power athletes
Published: 08.08.2016; Views: 1822; Downloads: 114
URL Full text (0,00 KB)

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