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14. Populacijska dinamika polipov uhatega klobučnjaka (Aurelia aurita) v koprskem zalivu : zaključna nalogaSara Hočevar, 2013, undergraduate thesis Keywords: polipi, uhati klobučnjak, množična pojavljanje, nespolno razmnoževanje, strobilacija, dinamika, okoljski parametri, polyps, moon jellyfish, mass occurence, asexual reproduction, strobilation, dynamics, environmental parameters Published in RUP: 22.11.2017; Views: 2140; Downloads: 42 Link to full text |
15. Evolutionary suicide of pathogensBarbara Boldin, Éva Kisdi, 2017, published scientific conference contribution abstract Keywords: adaptivna dinamika, matematični model, nalezljiva bolezen, virulenca, adaptive dynamics, mathematical model, infectious disease, virulence Published in RUP: 16.11.2017; Views: 3342; Downloads: 18 Link to full text |
16. Evolution of mate - finding Allee effect in preyVeronika Bernhauerová, Luděk Berec, Barbara Boldin, 2017, published scientific conference contribution abstract Keywords: adaptivna dinamika, Alleejev učinek, plenilec, plen, matematični model, adaptive dynamics, Allee effect, predator, prey, mathematical model Published in RUP: 16.11.2017; Views: 2429; Downloads: 137 Link to full text |
17. Levelling the playing field : the effects of Slovenia's 2013 labour market reformMatija Vodopivec, Suzana Laporšek, Milan Vodopivec, 2016, treatise, preliminary study, study Keywords: varovanje zaposlitve, dinamika trga dela, segmentacija trga dela, employment protection legislation, labor market dynamics, labor market segmentation Published in RUP: 08.08.2016; Views: 3605; Downloads: 84 Link to full text |
18. Evolutionary suicide through a non-catastrophic bifurcation : adaptive dynamics of pathogens with frequency-dependent transmissionBarbara Boldin, Éva Kisdi, 2016, original scientific article Keywords: adaptivna dinamika, evolucija do izumrtja, nekatastrofična bifurkacija, transkritična bifurkacija, izumrtje, virulenca, incidenca, adaptive dynamics, evolutionary suicide, noncatastrophic bifurcation, transcritical bifurcation, extinction, virulence, frequency-dependent incidence Published in RUP: 08.08.2016; Views: 2885; Downloads: 125 Link to full text |
19. H274Y's effect on oseltamivir resistance : what happens before the drug enters the binding siteMuhammad Yusuf, Nornisah Mohamed, Suriyati Mohamad, Dušanka Janežič, K. V. Damodaran, Habibah A. Wahab, 2016, original scientific article Abstract: Increased reports of oseltamivir (OTV)-resistant strains of the influenza virus, such as the H274Y mutation on its neuraminidase (NA), have created some cause for concern. Many studies have been conducted in the attempt to uncover the mechanism of OTV resistance in H274Y NA. However, most of the reported studies on H274Y focused only on the drug-bound system, so the direct effects of the mutation on NA itself prior to drug binding still remain unclear. Therefore, molecular dynamics simulations of NA in apo form, followed by principal component analysis and interaction energy calculations, were performed to investigate the structural changes of the NA binding site as a result of the H274Y mutation. It was observed that the disruption of the NA binding site due to the H274Y mutation was initiated by the repulsive effect of Y274 on the 250-loop, which in turn altered the hydrogen-bonding network around residue 274. The rotated W295 side chain caused the upward movement of the 340-loop. Consequently, sliding box docking results suggested that the binding pathway of OTV was compromised because of the disruption of this binding site. This study also highlighted the importance of the functional group at C6 of the sialic acid mimicry. It is hoped that these results will improve the understanding of OTV resistance and shed some light on the design of a novel anti-influenza drug. Keywords: influenza, neuraminidase, H274Y, oseltamivir, molecular dynamics Published in RUP: 08.08.2016; Views: 2796; Downloads: 144 Link to full text |
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