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1.
Mitochondrial phylogeography of the edible dormouse (Glis glis) in the western Palearctic region
Helene Hürner, Boris Kryštufek, Maurizio Sará, Alexis Ribas, Tanja Ruch, R. Sommer, Victoria Ivashkina, Jochan R. Michaux, 2010, izvirni znanstveni članek

Opis: This study describes in detail the phylogeographic pattern of the edible dormouse (Glis glis) a European rodent with pronounced hibernating behavior. We used sequences of 831 base pairs of the mitochondrial DNA cytochrome-b gene from 130 edible dormice collected at 43 localities throughout its distribution. Our results reveal presence of 3 main haplogroups: Sicilian, South Italian (restricted to the Calabrian region), and European (a widespread lineage corresponding to all remaining western, central, and eastern European populations). Examination of paleontological data confirms refugial regions for G. glis in the 3 Mediterranean peninsulas, although overall low genetic diversity is found. The low diversity of the European lineage is probably the result of a recent expansion (dated around 2,000 years ago) from a single refugium. Other factors, such as the ecological constraints on the species, may have caused genetic bottlenecks that reinforced the low genetic variability of G. glis. This work could have important implications for strategies to conserve the edible dormouse by defining important areas for their conservation.
Najdeno v: ključnih besedah
Ključne besede: dormouse, Glis-glis, glacial refugia, mitochondrial DNA, phylogeography, Europe
Objavljeno: 15.10.2013; Ogledov: 1486; Prenosov: 52
URL Polno besedilo (0,00 KB)

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Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training
Desy Salvadego, R. Domenis, Stefano Lazzer, Simone Porcelli, Joern Rittweger, Giovanna Rizzo, I. Mavelli, Boštjan Šimunič, Rado Pišot, Bruno Grassi, 2013, izvirni znanstveni članek

Opis: Oxidative function during exercise was evaluated in 11 young athletes with marked skeletal muscle hypertrophy induced by long-term resistance training (RTA, body mass 102.67.3 kg, meanSD) and 11 controls (CTRL, body mass 77.86.0). Pulmonary O2 uptake (V'O2) and vastus lateralis muscle fractional O2 extraction (by near-infrared spectroscopy) were determined during an incremental cycle ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers obtained by biopsy. Quadriceps femoris muscle cross sectional area, volume (determined by magnetic resonance imaging) and strength were greater in RTA vs. CTRL (by ~40%, ~33% and ~20%, respectively). V'O2peak during CE was higher in RTA vs. CTRL (4.050.64 L min-1 vs. 3.560.30); no difference between groups was observed during KE. The O2 cost of CE exercise was not different between groups. When divided per muscle mass (for CE) or quadriceps muscle mass (for KE) V'O2peak was lower (by 15-20%) in RTA vs. CTRL. Vastus lateralis fractional O2 extraction was lower in RTA vs. CTRL at all work rates, both during CE and KE. RTA had higher ADP-stimulated mitochondrial respiration (56.723.7 pmolO2s-1mg-1 ww) vs. CTRL (35.710.2), and a tighter coupling of oxidative phosphorylation. In RTA the greater muscle mass and maximal force, and the enhanced mitochondrial respiration seem to compensate for the hypertrophy-induced impaired peripheral O2 diffusion. The net results are an enhanced whole body oxidative function at peak exercise, and unchanged efficiency and O2 cost at submaximal exercise, despite a much greater body mass
Najdeno v: ključnih besedah
Povzetek najdenega: ...ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution...
Ključne besede: skeletal muscle, hypertrophy, mitochondrial respiration, oxidative metabolism, exercise
Objavljeno: 15.10.2013; Ogledov: 2059; Prenosov: 58
URL Polno besedilo (0,00 KB)

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Pljučna fibroza kot posledica motenega mitohondrijskega metabolizma in biogeneze
Tea Janko, 2018, diplomsko delo

Najdeno v: ključnih besedah
Povzetek najdenega: ...lung fibrosis, systemic sclerosis, expression profiling, mitochondrial metabolism, biogenesis...
Ključne besede: lung fibrosis, systemic sclerosis, expression profiling, mitochondrial metabolism, biogenesis
Objavljeno: 17.09.2018; Ogledov: 336; Prenosov: 9
URL Polno besedilo (0,00 KB)

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