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182. Odčitljivost digrafov in dvodelnih grafov : zaključna nalogaVladan Jovičić, 2016, undergraduate thesis Keywords: readability, overlap graph, labeling, integer linear program, distinctness, decomposition, HUB-number, two-dimensional grid graphs, toroidal grid graphs
Published in RUP: 09.08.2016; Views: 2627; Downloads: 38
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183. Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectivenessMaja Čemažar, Vesna Todorović, Janez Ščančar, Urša Lampreht Tratar, Monika Savarin, Urška Kamenšek, Simona Kranjc Brezar, Andrej Cör, Gregor Serša, 2015, original scientific article Abstract: Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most suitable for clinical use. Intravenous administration of cisplatin for electrochemotherapy is still not widely accepted in the clinics, presumably due to its lower antitumor effectiveness, but adjuvant therapy by immunomodulatory or vascular-targeting agents could provide a way for its potentiation. Hence, the aim of the present study was to explore the possibility of adjuvant tumour necrosis factor % (TNF-%) therapy to potentiate antitumor effectiveness of electrochemotherapy with intravenous cisplatin administration in murine sarcoma. Materials and methods. In vivo study was designed to evaluate the effect of TNF-% applied before or after the electrochemotherapy and to evaluate the effect of adjuvant TNF-% on electrochemotherapy with different cisplatin doses. Results. A synergistic interaction between TNF-% and electrochemotherapy was observed. Administration of TNF-% before the electrochemotherapy resulted in longer tumour growth delay and increased tumour curability, and was significantly more effective than TNF-% administration after the electrochemotherapy. Tumour analysis revealed increased platinum content in tumours, TNF-% induced blood vessel damage and increased tumour necrosis after combination of TNF-% and electrochemotherapy, indicating an anti-vascular action of TNF-%. In addition, immunomodulatory effect might have contributed to curability rate of the tumours. Conclusion. Adjuvant intratumoural TNF-% therapy synergistically contributes to electrochemotherapy with intravenous cisplatin administration. Due to its potentiation at all doses of cisplatin, the combined treatment is predicted to be effective also in tumours, where the drug concentration is suboptimal or in bigger tumours, where electrochemotherapy with intravenous cisplatin is not expected to be sufficiently effective.
Keywords: electrochemotherapy, TNF, adjuvant immunotherapy, cisplatin
Published in RUP: 09.08.2016; Views: 5718; Downloads: 135
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184. Long-term corrosion behavior and biocompatibility testing of titanium-based alloy covered with nano-crystalline hydroxyapatiteMonica Popa, Cora Vasilescu, Silviu Iulian Drob, Julija Hmeljak, Andrej Cör, Jose Maria Calderon Moreno, 2015, original scientific article Abstract: In this paper, we applied on the surface of the new Ti%20Nb%10Zr%5Ta alloy nano-crystalline hydroxyapatite (HA) coating by the method of the chemical deposition in a solution supersaturated with Ca2+ and inline image ions. The composition and crystallinity of the obtained coating was determined by X-ray diffraction, micro-Raman, infrared, and energy dispersive X-ray spectroscopies and its morphology and porosity by scanning electron microscopy. The coating long-term corrosion behavior for 3000 soaking hours in simulated human fluids (Ringer's solutions of different pH values) was studied by cyclic potentiodynamic and linear polarization, electrochemical impedance spectroscopy and monitoring of the open circuit potentials and corresponding open circuit potential gradient due to the pH non-uniformity of the biofluid. Also, the coating biocompatibility was performed by cells (human osteoblast % HOS and human immortalized pulmonary fibroblast % Wi-38) adhesion and proliferation testing in the HA coated bioalloy extract compared to respective effects of the un-coated bioalloy extract. The initial HA nano-coating promoted the deposition of new HA layers, thickening itself and showing its ability to induce the formation of this main inorganic component of the human bone, therefore denoting bioactivity of the HA nano-coated alloy.
Keywords: bioactive hydroxyapatite, corrosion behavior, EDX, FT-IR, Raman micro-spectroscopy, SEM, XRD
Published in RUP: 09.08.2016; Views: 3908; Downloads: 209
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186. Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathingHelio Fernandez Tellez, Shawnda A. Morrison, X Neyt, O. Mairesse, Maria Francesca Piacentini, E Macdonald-Nethercott, Andrej Pangerc, Leja Dolenc-Grošelj, Ola Eiken, Nathalie Pattyn, Igor B. Mekjavić, Romain Meeusen, 2016, original scientific article Keywords: sleep apnea, confinement, cycling, high altitude, oxygen saturation, Antarctica
Published in RUP: 08.08.2016; Views: 3579; Downloads: 365
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