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Kanibalizacija trgovske in proizvodne blagovne znamke
Andrej Blažko, 2010, undergraduate thesis

Found in: osebi
Keywords: blagovne znamke, kanibalizem, kupci, mlečni izdelki, tržne raziskave
Published: 15.10.2013; Views: 3508; Downloads: 88
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The central role of survivin in proliferation and apoptosis of malignant pleural mesothelioma
Julija Hmeljak, Andrej Cör, 2012, independent scientific component part or a chapter in a monograph

Found in: osebi
Keywords: survivin, proliferation, malignant mesothelioma, oncology
Published: 15.10.2013; Views: 1674; Downloads: 52
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Aseptic loosening of total hip arthroplasty as a result of local failure of tissue homeostasis
Jiří Gallo, Rihard Trebše, Andrej Cör, 2012, independent scientific component part or a chapter in a monograph

Found in: osebi
Keywords: kolčne proteze, kolki, artroplastike, homeostaze, aseptično omajanje
Published: 15.10.2013; Views: 1888; Downloads: 67
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Histological analysis of periprosthetic tissue for detecting prosthetic joint infection
Andrej Cör, 2012, independent scientific component part or a chapter in a monograph

Found in: osebi
Keywords: diagnosis, histology, frozen sections, samplings
Published: 15.10.2013; Views: 1550; Downloads: 72
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[Uporaba gensko spremenjenih mikroorganizmov v genski terapiji raka
2012, radio or television event

Found in: osebi
Keywords: onkologija, rak, zdravljenje raka, srečanje Ad Salutem, oddaja Univerza, Fakulteta za vede o zdravju
Published: 15.10.2013; Views: 1932; Downloads: 15
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Presence and role of Simian Virus 40 (SV40) in malignant pleural mesothelioma
Julija Hmeljak, Andrej Cör, 2009, review article

Found in: osebi
Keywords: viral carcinogenesis, simian virus 40, mesothelioma, T antigen
Published: 10.07.2015; Views: 1510; Downloads: 53
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Human beta-defensin-3 producing cells in septic implant loosening
Andrej Cör, Rihard Trebše, Jaakko Levón, Ahmed Al-Samadi, Zygmunt Mackiewicz, Eero Waris, Yrjö T. Konttinen, 2015, original scientific article

Abstract: Abstract Human ß-defensin-3 (hBD-3) has been found in synovial fluid and later in periprosthetic tissues in septic joint implant loosening. The aim of the present study was to identify its cellular sources. Tissue samples from 12 patients were analyzed. A fully automatic Leica BOND MAX staining robot was used. Affinity-purified rabbit anti-human hBD-3 IgG was applied in a two-layer horse radish peroxidase/anti-rabbit-labeled polymer method. Double immunofluorescence of hBD3 together with CD68, CD31, heat shock protein 47 (HSP47) and mast cell tryptase (MCT) staining was done. Human BD-3 was found in monocyte/macrophage-like cells, vascular endothelial cells and fibroblasts-like cells, but was weakly expressed in foreign body giant cells and negative in neutrophils. Human BD-3 was found in CD68 and CD31 immunoreactive cells, whereas HSP47 and MCT positive cells were hBD-3 negative. Immunostaining of hBD-3 was strong in some tissue areas but weak or absent in others. Monocyte/macrophages and endothelial cells were established in this study as the major cellular sources of hBD-3 in septic loosening, but fibroblasts and foreign body giant cells can also contribute to its production. The heterogeneous topological staining of hBD-3 suggests local regulation, possibly by bacterial products, damage-associated molecular patterns and cytokines. The results explain the increased synovial fluid/tissue concentrations of hBD-3 in septic loosening.
Found in: osebi
Keywords: beta-defensin 3, septic loosening, arthroplasty
Published: 14.10.2015; Views: 1255; Downloads: 228
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Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness
Maja Čemažar, Andrej Cör, Vesna Todorović, Janez Ščančar, Simona Kranjc, Gregor Serša, Urška Kamenšek, Monika Štimac, Urša Lampreht Tratar, 2015, original scientific article

Abstract: Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most suitable for clinical use. Intravenous administration of cisplatin for electrochemotherapy is still not widely accepted in the clinics, presumably due to its lower antitumor effectiveness, but adjuvant therapy by immunomodulatory or vascular-targeting agents could provide a way for its potentiation. Hence, the aim of the present study was to explore the possibility of adjuvant tumour necrosis factor % (TNF-%) therapy to potentiate antitumor effectiveness of electrochemotherapy with intravenous cisplatin administration in murine sarcoma. Materials and methods. In vivo study was designed to evaluate the effect of TNF-% applied before or after the electrochemotherapy and to evaluate the effect of adjuvant TNF-% on electrochemotherapy with different cisplatin doses. Results. A synergistic interaction between TNF-% and electrochemotherapy was observed. Administration of TNF-% before the electrochemotherapy resulted in longer tumour growth delay and increased tumour curability, and was significantly more effective than TNF-% administration after the electrochemotherapy. Tumour analysis revealed increased platinum content in tumours, TNF-% induced blood vessel damage and increased tumour necrosis after combination of TNF-% and electrochemotherapy, indicating an anti-vascular action of TNF-%. In addition, immunomodulatory effect might have contributed to curability rate of the tumours. Conclusion. Adjuvant intratumoural TNF-% therapy synergistically contributes to electrochemotherapy with intravenous cisplatin administration. Due to its potentiation at all doses of cisplatin, the combined treatment is predicted to be effective also in tumours, where the drug concentration is suboptimal or in bigger tumours, where electrochemotherapy with intravenous cisplatin is not expected to be sufficiently effective.
Found in: osebi
Keywords: electrochemotherapy, TNF, adjuvant immunotherapy, cisplatin
Published: 09.08.2016; Views: 3251; Downloads: 99
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