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Effect of ionizing radiation on human skeletal muscle precursor cells
Tomaž Marš, Maja Čemažar, Mihaela Jurdana, Katarina Pegan, 2013, published scientific conference contribution

Abstract: Background. Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures.Materials and methods. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin - 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death.Results. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70).Conclusions. Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions.
Found in: osebi
Keywords: myoblasts, irradiation, proliferation, interleukin 6, muscle regeneration, apoptosis
Published: 30.12.2015; Views: 1878; Downloads: 104
URL Full text (0,00 KB)

Elevated serum levels of cysteine and tyrosine
Nina Mohorko, Gianni Biolo, Zala Jenko Pražnikar, Mihaela Jurdana, Ana Petelin, 2015, original scientific article

Found in: osebi
Keywords: metabolic syndrome, biomarkers, amino acids
Published: 09.08.2016; Views: 2049; Downloads: 56
URL Full text (0,00 KB)

Vpliv skeletne mišičnine na zdravje
Karin Trošt, 2018, undergraduate thesis

Found in: osebi
Keywords: zdravje, telesna aktivnost, skeleta mišičnina, miokini
Published: 07.06.2018; Views: 1238; Downloads: 64
.pdf Full text (588,35 KB)

Vpliv mikro in makrohranil na zdravje in funkcionalnost kože
Zala Mlinšek, 2018, undergraduate thesis

Found in: osebi
Keywords: mikrohranila, makrohranila, koža, prehrana
Published: 27.07.2018; Views: 423; Downloads: 33
.docx Full text (586,85 KB)

Vpliv vitamina D na astmo
Erika Berce, 2018, undergraduate thesis

Found in: osebi
Keywords: vitamin D, astma, imunski sistem, glukokortikoidi
Published: 31.07.2018; Views: 803; Downloads: 34
.pdf Full text (488,29 KB)

Prehranska dopolnila pri rakavi kaheksiji
Nina Medved, 2018, undergraduate thesis

Found in: osebi
Keywords: rak, kaheksija, prehranska dopolnila
Published: 05.09.2018; Views: 857; Downloads: 60
.pdf Full text (628,97 KB)

Vpliv mikrogravitacije na upad skeletno mišične mase
Alja Ivetac, 2018, undergraduate thesis

Found in: osebi
Keywords: mikrogravitacija, mišica, atrofija, anabolna rezstenca, prehrana
Published: 08.11.2018; Views: 482; Downloads: 26
.pdf Full text (813,65 KB)

Telesna aktivnost otrok z motnjo avtističnega spektra
Lea Zvonar, 2018, undergraduate thesis

Found in: osebi
Keywords: telesna aktivnost, prilagoditev, motnje avtističnega spektra, gibalne sposobnosti
Published: 18.01.2019; Views: 574; Downloads: 28
.pdf Full text (932,12 KB)

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