1. Transkranialna magnetna stimulacija (TMS) za terapevtske namene : zaključna nalogaKristjan Bajec, 2018, diplomsko delo Ključne besede: TMS, rTMS, depresija, parametri stimulacije, efektivnost terapije, možganska aktivnost, TMS, rTMS, depression, stimulation parameters, therapy effectiveness, brain activity
Objavljeno v RUP: 17.04.2018; Ogledov: 5003; Prenosov: 70
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2. A novel device to preserve physical activities of daily living in healthy older peopleWolfram Haslinger, Lisa Müller, Nejc Šarabon, Christian Raschner, Helmut Kern, Stefan Loefler, 2015, izvirni znanstveni članek Opis: Objective: To determine the effectiveness of exercise in improving sensorimotor function and functional performance as crucial part of activities of daily living in healthy older adults. Design: RCT. Setting: Laboratory. Participants: 39 subjects (M = 71.8 years, range: 61%89 years). Intervention: Task oriented visual feedback balance training. Primary outcome measure: Timed up & go (TUG). Secondary outcome measures: Chair stand test (CST), self-paced walk test, maximum isometric torque, quiet stand posturography and dynamic balance (DB). Results: Post intervention comparison of the treatment group (TG) and control group (CG) showed better TUG (p < .01), CST (p < .001) and DB (p < .025) for the TG. Pre%post intervention comparison of the TG showed better clinically relevant outcomes in TUG (p < .001), CST (p < .001) and DB (p < .001). Conclusion: Active driven visual feedback balance training is effective in improving functional performance and dynamic balance in older adults.
Ključne besede: posturalno ravnotežje, gibalna terapija, staranje, funkcionalna sposobnost, postural balance, exercise therapy, ageing, functional performance
Objavljeno v RUP: 03.04.2017; Ogledov: 2459; Prenosov: 204
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3. Endoglin (CD105) silencing mediated by shRNA under the control of Endothelin-1 promoter for targeted gene therapy of MelanomaNataša Tešić, Urška Kamenšek, Gregor Serša, Simona Kranjc Brezar, Monika Savarin, Urša Lampreht Tratar, Véronique Préat, Gaëlle Vandermeulen, Miha Butinar, Boris Turk, Maja Čemažar, 2015, izvirni znanstveni članek Opis: Endoglin (CD105), a transforming growth factor (TGF)-% coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a eukaryotic expression plasmid encoding the shRNA molecules against CD105 under the control of endothelin-1 promoter and to evaluate its therapeutic potential both in vitro in murine B16F10-luc melanoma and SVEC4-10 endothelial cells and in vivo in mice bearing highly metastatic B16F10-luc tumors. Plasmid encoding shRNA against CD105 under the control of the constitutive U6 promoter was used as a control. We demonstrated the antiproliferative and antiangiogenic effects of both plasmids in SVEC4-10 cells, as well as a moderate antitumor and pronounced antimetastatic effect in B16F10-luc tumors in vivo. Our results provide evidence that targeting melanoma with shRNA molecules against CD105 under the control of endothelin-1 promoter is a feasible and effective treatment, especially for the reduction of metastatic spread.
Ključne besede: melanoma, electroporation, endoglin (CD105), endothelin-1, gene therapy
Objavljeno v RUP: 14.10.2015; Ogledov: 3741; Prenosov: 131
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