20.500.12556/RUP-21713 Radiation-induced impairment of skeletal muscle regeneration Background. Radiotherapy is a cornerstone of treatment for various cancers, but often causes collateral damage to surrounding healthy tissue, including skeletal muscle. Ionizing radiation leads to oxidative stress and inflammation, which impairs the regenerative capacity of muscle tissue. Irradiation reduces the number and functionality of satellite cells and disrupts the tightly regulated processes of myogenesis and tissue remodelling. In addition, irradiation alters the muscle microenvironment by promoting fibrosis and vascular damage, which further impedes effective regenera-tion. Cytokine signalling pathways are also dysregulated following irradiation, contributing to impaired activation and differentiation of satellite cells. Conclusions. There is evidence that factors such as melatonin and growth factors can improve muscle regenera-tion. Understanding the molecular and cellular mechanisms underlying the impairment of muscle regeneration after radiotherapy is crucial for the development of targeted strategies to mitigate side effects and improve patients’ qual-ity of life. Overall, the preservation and restoration of muscle function in irradiated tissue remains a critical challenge that requires multidisciplinary approaches skeletal muscle radiotherapy muscle regeneration melatonine skeletna mišičnina radioterapija mišična regeneracija melatonin true false false Angleški jezik Slovenski jezik Članek v reviji 2025-09-11 00:06:48 2025-09-11 00:06:48 2025-10-01 03:03:20 0000-00-00 00:00:00 2025 0 0 str. 293–300 no. 3 Vol. 59 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-09-08 615.849:616.74 1318-2099 10.2478/raon-2025-0048 248491779 https://www.radioloncol.com/index.php/ro/article/view/4676 1 8a3f6b11-8e92-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=31547 http://doi.org/10.2478/raon-2025-0048 1 8aae47fa-8e92-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=31548 RAZ_Cemazar_Maja_2025.pdf RAZ_Cemazar_Maja_2025.pdf 1 407F546FE0D0373EE610D8A96C032042 5f8046635e1ea815143c17e681fd0de41c2c515b06d722ff15d10bb007edbea9 ba438cde-8e92-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=31549 Fakulteta za vede o zdravju 0 0 0