20.500.12556/RUP-22043 Postural sway in multiple sclerosis patients interaction of vision, surface, and fatigue effects Introduction: Postural control impairments are common in patients with multiple sclerosis (MS), resulting in postural instability and increased fall risk. Sensory inputs are crucial to maintain balance adequately. Additionally, fatigue is one of the common and most disabling symptoms of MS, possibly contributing to postural deficits. Previous studies have examined the effects of fatigue and altered sensory conditions on postural control in patients with MS. The present study aimed to extend this knowledge by jointly assessing these factors within the same experimental framework, providing additional insight into how fatigue modulates sensory contributions to balance. Methods: A total of 21 patients with MS (age = 41.1 ± 10.1 years; EDSS = 1.9 ± 1.0; disease duration = 6.8 ± 4.9 years) completed balance assessments on firm and compliant surfaces with both eyes open and eyes closed, before and after a 6-min walk test used to induce fatigue. Postural sway was quantified using sway velocity and root mean square (RMS). Results: There was a significant effect of surface on sway velocity (p < 0.001, η2 = 0.60), with a greater sway on the compliant surface compared to the firm surface. Fatigue significantly increased sway RMS (p = 0.023, η2 = 0.23) but did not affect sway velocity (p > 0.05). The absence of visual input (eyes closed) also significantly increased sway RMS (p = 0.001, η2 = 0.46). There was a significant interaction between surface and vision for sway RMS (p < 0.001, η2 = 0.54), with a larger effect of surface instability in the eyes-closed condition. Discussion: Patients with MS face increased challenges in maintaining postural control under conditions of fatigue, surface instability, and lack of visual input. Sway RMS may be more sensitive to these effects than sway velocity. balance control sensory integration proprioception motor impairments fall prevention neurological disorders physical fatigue nadzor ravnotežja senzorična integracija propriocepcija motorične okvare preprečevanje padcev nevrološke motnje true false true Angleški jezik Slovenski jezik Članek v reviji 2025-10-27 01:02:35 2025-10-27 01:02:39 2025-11-16 03:06:17 0000-00-00 00:00:00 2025 0 0 str. 1-7 [article no.] 1624969. Vol. 19 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 2025-10-06 2025-10-21 616.8 1662-5161 10.3389/fnhum.2025.1624969 254790147 https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1624969/full 1 72582d83-b2c8-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=31979 https://doi.org/10.3389/fnhum.2025.1624969 1 73a4fedd-b2c8-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=31980 RAZ_Kozinc_Ziga_2025.pdf RAZ_Kozinc_Ziga_2025.pdf 1 3F62CD32DCC6BE0F16A157DD11913134 3191ffc5a77b9496750bc4a836bb9658da8e9863aeb24bc96519a71a2707a00d 98d2a6dd-b2c8-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=31981 Fakulteta za vede o zdravju 0 0 0