20.500.12556/RUP-22301 Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient journey in the era of anti-amyloid monoclonal antibodies for Alzheimer’s disease. Emphasizing a multidisciplinary and integrated approach, the document recommends a patient journey that begins with early identification of cognitive impairment by General Practitioners, continues with specialized assessments at Memory and Dementia Centres, and leads, in carefully selected cases, to initiation of anti-amyloid monoclonal antibody therapy. It advocates the rational use of diagnostic tools, including plasma and cerebrospinal fluid biomarkers, advanced neuroimaging (MRI and PET), and genetic profiling (ApoE genotyping), not only to identify eligible patients but also to stratify those requiring alternative care strategies. The paper further defines minimum requirements for the accreditation of prescribing and infusion centres, highlighting the clinical competencies, structural resources, and inter-professional communication protocols necessary to ensure safety and appropriateness. Recognizing both the therapeutic potential and the organizational challenges associated with anti-amyloid monoclonal antibodies, the document aims to guide healthcare policymakers, institutions, and practitioners toward a coordinated reorganization of the diagnostic-therapeutic pathway, ensuring the safe and effective use of these treatments and ultimately improving outcomes and quality of care for individuals with Alzheimer’s disease. Alzheimer’s disease disease-modifying therapies anti-amyloid monoclonal antibodies biomarkers clinical implementation Alzheimerjeva bolezen terapije antiamiloidna monoklonska protitelesa biomarkerji implementacija true false false Angleški jezik Slovenski jezik Članek v reviji 2025-12-22 11:58:53 2025-12-22 11:58:56 2025-12-27 03:05:35 0000-00-00 00:00:00 2025 0 0 str. 6875-6894 iss. 12 Vol. 46 Dec. 2025 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 2025-10-17 616.892.3 1590-3478 10.1007/s10072-025-08576-y 262538243 RAZ_Benussi_Alberto_2025.pdf RAZ_Benussi_Alberto_2025.pdf 1 D149BC4E6F34CD1710EA1D35FEE4FDC4 7b9a13ed5e2412bd733cfa9910a4ed70eb03081867bc88b7c13920f1e23ad542 a9ebcc18-df25-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32386 https://link.springer.com/article/10.1007/s10072-025-08576-y 1 87bd907c-df25-11f0-8f0b-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32385 Inštitut Andrej Marušič 0 0 0