20.500.12556/RUP-22664 Disease severity affects knee range of motion but not strength deficits in knee osteoarthritis a systematic review and meta-analysis Objectives: To compare knee range of motion and muscle strength between individuals with symptomatic knee osteoarthritis and healthy controls, and to assess how Kellgren–Lawrence grade and measurement protocols affect these outcomes.Methods: A systematic search of PubMed, Scopus, and Web of Science identified studies comparing knee flexion/extension range of motion or flexor/extensor strength between patients with knee osteoarthritis and controls. Risk of bias was assessed with Joanna Briggs Institute tools. Pooled mean and standardized mean differences with 95% confidence intervals were calculated using random-effects meta-analyses.Results: Thirty studies were included. Compared with healthy controls, individuals with knee osteoarthritis showed significantly reduced knee flexion [MD = 16.30°, 95%CI (11.40, 21.21)] and extension [MD = 4.25°, 95%CI (2.30, 6.19)], with greater flexion loss in advanced KL grades. Knee osteoarthritis participants also demonstrated significantly lower strength across all contraction types: isometric [extensors: SMD = 0.86, 95%CI (0.57, 1.14); flexors: SMD = 0.52, 95%CI (0.30, 0.74)], concentric [extensors: SMD = 1.07, 95%CI (0.65, 1.50); flexors: SMD = 0.77, 95%CI (0.43, 1.12)], and eccentric extensor strength. Strength deficits were consistent across Kellgren–Lawrence grades, knee joint angles, and angular velocities during testing.Conclusions: Individuals with symptomatic knee osteoarthritis present with marked reductions in knee range of motion and strength. While range of motion impairments worsen with disease severity, strength deficits are stable across Kellgren–Lawrence grades and measurement protocols. Given the very low to low certainty of evidence, results should be interpreted with caution. 1 Introduction osteoarthritis knee arthritis risk factors rehabilitation osteoartritis koleno artritis dejavniki tveganja rehabilitacija true false true Angleški jezik Slovenski jezik Članek v reviji 2026-02-18 00:09:00 2026-02-18 00:09:00 2026-02-18 03:05:30 0000-00-00 00:00:00 2026 0 0 str. [article no.] 1737973 Vol. 13 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 2026-01-28 2026-02-13 615.8 2296-858X 10.3389/fmed.2026.1737973 268788995 https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1737973/full 1 a85711e8-0c55-11f1-b092-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32984 https://doi.org/10.3389/fmed.2026.1737973 1 a9b80c8c-0c55-11f1-b092-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32985 RAZ_Opara_Manca_Zupancic_2026.pdf RAZ_Opara_Manca_Zupancic_2026.pdf 1 43A43AF8AEEFA1B9C60C14FF67B9ABFB 6e39c5a881a25e318ce7d9a1bff096e257a4ddb949cfd2c6853b919acbb4c61b e5f9f786-0c55-11f1-b092-005056ac49c0 https://repozitorij.upr.si/Dokument.php?lang=slv&id=32986 Fakulteta za vede o zdravju 0 0 0