Search the repository

Keywords: blockchain, centralized/decentralized marketplace, games, marketing, liquidity, NFT, player retention, game engagement
Published in RUP: 04.10.2025; Views: 412; Downloads: 4
Full text (950,47 KB)

Abstract: This paper describes an open-source computational tool developed for the modeling and simulation of fed-batch bioreactors, particularly for processes employing Chinese Hamster Ovary (CHO) cells, which are integral to biopharmaceutical manufacturing. The software provides a platform for researchers and industry professionals to simulate bioreactor dynamics and investigate the impact of various operational parameters, such as nutrient supply rates, oxygen concentrations, and temperature, prior to physical experimentation. The tool enables users to generate predictions of critical variables including cell density, nutrient consumption, and product concentration profiles over time. These predictions are derived from a mathematical framework based on a system of ordinary differential equations solved using the Runge–Kutta method. A notable capability of the software is the import of experimental data and the application of the Nelder–Mead algorithm for parameter optimization, allowing for the calibration of the model against empirical findings, thereby enhancing its predictive accuracy. The software supports in silico experimentation, which can contribute to reducing the time, cost, and resources associated with optimizing bioreactor configurations and scaling up production processes. By providing a refined and adaptable framework, this instrument assists in improving the understanding of bioreactor dynamics, optimizing biopharmaceutical production methodologies, and correlating theoretical models with practical bioreactor operations. The software is available as an open-source project to promote its adoption and continued development within the scientific community.
Keywords: bioreaktor, mathematical modeling, CHO
Published in RUP: 29.09.2025; Views: 527; Downloads: 4
Full text (939,94 KB)
This document has more files! More...

Keywords: container migration, CRIU, decentralised systems, Docker, verifiability, final projects
Published in RUP: 06.09.2025; Views: 464; Downloads: 1
Full text (660,67 KB)

Abstract: Retrieval-Augmented Generation (RAG) systems synergize retrieval mechanisms with generative language models to enhance the accuracy and relevance of responses. However, bridging the style gap between user queries and relevant information in document text remains a persistent challenge in retrieval-augmented systems, often addressed by runtime solutions (e.g., Hypothetical Document Embeddings (HyDE)) that attempt to improve alignment but introduce extra computational overhead at query time. To address these challenges, we propose Hypothetical Prompt Embeddings (HyPE), a framework that shifts the generation of hypothetical content from query time to the indexing phase. By precomputing multiple hypothetical prompts for each data chunk and embedding the chunk in place of the prompt, HyPE transforms retrieval into a question-question matching task, bypassing the need for runtime synthetic answer generation. This approach does not introduce latency but also strengthens the alignment between queries and relevant context. Our experimental results on six common datasets show that HyPE can improve retrieval context precision by up to 42 percentage points and claim recall by up to 45 percentage points, compared to standard approaches, while remaining compatible with re-ranking, multi-vector retrieval, query decomposition, and other RAG advancements.
Keywords: LLM, hypothetical prompt embedding, Retrieval-Augmented Generation (RAG)
Published in RUP: 04.08.2025; Views: 635; Downloads: 4
Full text (1,41 MB)
This document has more files! More...

Abstract: Life-Cycle Assessment (LCA) is a methodology that is used extensively for evaluating the environmental impacts of products and processes throughout their lifetime. The method is highly dependent on the quality and accuracy of the underlying data. Moreover, the data acquisition process can be subjective, raising concerns about potential inconsistencies. In this study, we perform Benford’s law conformity tests (first digit) on all numerical data in ecoinvent, focusing on individual compartments (air, water, soil, and natural resources) and environmental elementary flows (carbon, toxic substances, greenhouse gases, and heavy metals), and discrepancies across continents are examined. Life Cycle Inventory data met the requirements of Benford’s law and generally exhibited high conformity. Substantial differences in conformity were observed between Africa and Europe. Individual processes and measurements were inspected to further isolate potential sources of the non-conformity. The statistical significance of the results was increased using open-source databases available on OpenLCA Nexus, including WorldSteel, OzLCI2019, ELCD, NEEDS, BioenergieDat, and Exiobase. Finally, the Environmental Performance Index (EPI) was used, and a strong correlation between continental Benford conformity results and corresponding EPI scores was observed. The findings suggest that discrepancies in conformity across continents reflect differences in data transparency and reporting practices. European datasets generally show higher conformity, likely owing to the use of more standardized methodologies. In contrast, data from regions with limited infrastructure or less established LCA practices tend to show lower conformity. Benford’s Law offers a simple and computationally efficient alternative to conventional data quality assessments without requiring additional metadata or probabilistic modeling. Its application can support the detection of systemic biases and improve the reliability of LCA-based indicators such as environmental product declarations.
Keywords: anomaly detection, Benford’s law, data integrity
Published in RUP: 12.06.2025; Views: 2338; Downloads: 35
Full text (1,41 MB)
This document has more files! More...