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3. The usefulness of a body shape index in assessing muscle function and strength in older adults hemodialysis patients : aBojan Knap, Boštjan Žvanut, Lucija Brezočnik, Mihaela Jurdana, 2025, original scientific article Abstract: Objective: This study investigates the relationship between a new anthropometric measure, the Body Shape Index (ABSI), and body composition and biochemical parameters in hemodialysis patients and, for the first time, the correlation between ABSI and muscle strength and function in these patients. Methods: A cross-sectional study was conducted on a sample of 80 patients who were regularly treated in the hemodialysis unit of a single medical center of the University Hospital of Ljubljana, Slovenia. General anthropometric parameters body mass index (BMI) and ABSI=(WC/(BMI2/3x height½) as well as body composition data (fat mass FM, fat-free mass FFM, fat-free mass index FFMI, skeletal muscle index SMI) were determined in 25 women (aged 74.5 ± 7.5 years) and 55 men (aged 70.1 ± 6.6 years) with overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and obesity (BMI ≥ 30 kg/m2) by bioelectrical impedance analysis (BIA). Muscle strength was determined using a hand grip strength test, while muscle performance was assessed using the sit-to-stand test. Results: ABSI was significantly negatively associated with muscle strength, functional tests and SMI only in men. Based on the median ABSI value (0.090273 m11/6·kg−2/3 in women and 0.090893 m11/6·kg−2/3 in men), women with a higher ABSI had a significantly higher glucose concentration than those with a lower ABSI. Men with a lower ABSI obtained significantly better results in the hand grip test, sit-to-stand test and waist circumference (WC). In conclusion, our findings suggest an inverse association between ABSI and muscle strength and function in male hemodialysis patients, indicating that higher ABSI may reflect poorer physical condition in this population. Further longitudinal studies are needed to explore the clinical significance of this relationship.
Keywords: hemodialysis, muscle strenght, sarcopenia
Published in RUP: 10.11.2025; Views: 367; Downloads: 7
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4. Radiation-induced impairment of skeletal muscle regenerationMaja Čemažar, Mihaela Jurdana, 2025, review article Abstract: Background. Radiotherapy is a cornerstone of treatment for various cancers, but often causes collateral damage to surrounding healthy tissue, including skeletal muscle. Ionizing radiation leads to oxidative stress and inflammation, which impairs the regenerative capacity of muscle tissue. Irradiation reduces the number and functionality of satellite cells and disrupts the tightly regulated processes of myogenesis and tissue remodelling. In addition, irradiation alters the muscle microenvironment by promoting fibrosis and vascular damage, which further impedes effective regenera-tion. Cytokine signalling pathways are also dysregulated following irradiation, contributing to impaired activation and differentiation of satellite cells. Conclusions. There is evidence that factors such as melatonin and growth factors can improve muscle regenera-tion. Understanding the molecular and cellular mechanisms underlying the impairment of muscle regeneration after radiotherapy is crucial for the development of targeted strategies to mitigate side effects and improve patients’ qual-ity of life. Overall, the preservation and restoration of muscle function in irradiated tissue remains a critical challenge that requires multidisciplinary approaches
Keywords: skeletal muscle, radiotherapy, muscle regeneration, melatonine
Published in RUP: 11.09.2025; Views: 385; Downloads: 1
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6. Trendi pojavljanja večkratno odpornih bakterij v Splošni bolnišnici Izola v času pred, med in po pandemiji COVID-19 : magistrska nalogaGordana Valjak, 2025, master's thesis Keywords: protimikrobna odpornost, večkratno odporne bakterije, zdravstvena nega, COVID-19, Slovenija, Splošna bolnišnica Izola, magistrske naloge
Published in RUP: 06.07.2025; Views: 808; Downloads: 8
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