1. Effects of time-restricted eating (early and late) combined with energy restriction vs. energy restriction alone on the gut microbiome in adults with obesityBernarda Habe, Tanja Črešnovar, Matjaž Hladnik, Jure Pražnikar, Saša Kenig, Dunja Bandelj, Nina Mohorko, Ana Petelin, Zala Jenko Pražnikar, 2025, original scientific article Abstract: Background: Early time-restricted eating combined with energy restriction (eTRE + ER) has been shown to reduce fat mass, diastolic blood pressure (DBP) and fasting glucose more effectively than late TRE with energy restriction (lTRE + ER) or energy restriction (ER) alone. Given the gut microbiome’s sensitivity to circadian rhythms, we examined whether adding TRE, particularly eTRE, to ER alters gut microbiota composition beyond ER alone, and whether such effects persist during follow-up. Methods: We analysed anthropometric, biochemical and gut microbiome data from 76 participants at baseline and after a 3-month intervention (eTRE + ER: n = 33; lTRE + ER: n = 23; ER: n = 20). Follow-up microbiome data 6-months after the end of intervention were available for 43 participants. Gut microbiota composition was assessed via 16S rRNA gene sequencing of stool samples. Results: No significant between-group differences in beta diversity were observed over time. However, changes in alpha diversity differed significantly across groups at the end of the intervention (Shannon: F = 5.72, p < 0.001; Simpson: F = 6.72, p < 0.001; Richness: F = 3.99, p = 0.01) and at follow-up (Richness: F = 3.77, p = 0.02). lTRE + ER led to the greatest reductions in diversity post intervention, while ER was least favourable during follow-up. Although no significant between-group differences were observed at the phylum level either at the end of the intervention or during follow-up, only the eTRE + ER group exhibited a significant decrease in Bacillota and an increase in Bacteroidota during follow-up. At the genus level, differential abundance analysis revealed significant shifts in taxa such as Faecalibacterium, Subdoligranulum, and other genera within the Ruminococcaceae and Oscillospiraceae families. In the eTRE + ER, Faecalibacterium and Subdoligranulum increased, while in other groups decreased. Notably, the changes in Faecalibacterium were negatively correlated with fasting glucose, while the increase in Subdoligranulum was inversely associated with DBP; however, both associations were weak in strength. Conclusions: eTRE + ER may promote beneficial, lasting shifts in the gut microbiome associated with improved metabolic outcomes. These results support further research into personalized TRE strategies for treatment of obesity.
Keywords: eating window, energy restriction, microbiota, alpha and beta diversity, metabolic health, obesity
Published in RUP: 17.07.2025; Views: 678; Downloads: 7
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2. Primerjava strategij upravljanja finančnega premoženja vlagateljev : magistrska nalogaMarko Štingl, 2016, master's thesis Keywords: strategija upravljanja, aktivne in pasivne strategije, merjenje uspešnosti, donosnost, standardni odklon, koeficient Sharpe, Treynorjev koeficient, informacijski koeficient, koeficient beta
Published in RUP: 07.06.2021; Views: 2116; Downloads: 37
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8. Human beta-defensin-3 producing cells in septic implant looseningJaakko Levón, Ahmed Al-Samadi, Zygmunt Mackiewicz, Andrej Cör, Rihard Trebše, Eero Waris, Yrjö T. Konttinen, 2015, original scientific article Abstract: Abstract Human ß-defensin-3 (hBD-3) has been found in synovial fluid and later in periprosthetic tissues in septic joint implant loosening. The aim of the present study was to identify its cellular sources. Tissue samples from 12 patients were analyzed. A fully automatic Leica BOND MAX staining robot was used. Affinity-purified rabbit anti-human hBD-3 IgG was applied in a two-layer horse radish peroxidase/anti-rabbit-labeled polymer method. Double immunofluorescence of hBD3 together with CD68, CD31, heat shock protein 47 (HSP47) and mast cell tryptase (MCT) staining was done. Human BD-3 was found in monocyte/macrophage-like cells, vascular endothelial cells and fibroblasts-like cells, but was weakly expressed in foreign body giant cells and negative in neutrophils. Human BD-3 was found in CD68 and CD31 immunoreactive cells, whereas HSP47 and MCT positive cells were hBD-3 negative. Immunostaining of hBD-3 was strong in some tissue areas but weak or absent in others. Monocyte/macrophages and endothelial cells were established in this study as the major cellular sources of hBD-3 in septic loosening, but fibroblasts and foreign body giant cells can also contribute to its production. The heterogeneous topological staining of hBD-3 suggests local regulation, possibly by bacterial products, damage-associated molecular patterns and cytokines. The results explain the increased synovial fluid/tissue concentrations of hBD-3 in septic loosening.
Keywords: beta-defensin 3, septic loosening, arthroplasty
Published in RUP: 14.10.2015; Views: 4129; Downloads: 320
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10. On generalized Jordan triple ([alpha], [beta]) [sup] [ast]-derivations and related mappingsShakir Ali, Ajda Fošner, Maja Fošner, Mohammad Salahuddin Khan, 2013, original scientific article Abstract: Let ▫$R$▫ be a 2-torsion free semiprime ▫$\ast$▫-ring and let ▫$\alpha, \beta$▫ be surjective endomorphisms of ▫$R$▫. The aim of the paper is to show that every generalized Jordan triple ▫$(\alpha, \beta)^\ast$▫-derivation on ▫$R$▫ is a generalized Jordan ▫$(\alpha, \beta)^\ast$▫-derivation. This result makes it possible to prove that every generalized Jordan triple ▫$(\alpha, \beta)^\ast$▫-derivation on a semisimple ▫$H^\ast$▫-algebra is a generalized Jordan ▫$(\alpha, \beta)^\ast$▫-derivation. Finally, we prove that every Jordan triple left ▫$\alpha^\ast$▫-centralizer on a 2-torsion free semiprime ring is a Jordan left ▫$\alpha^\ast$▫-centralizer.
Keywords: mathematics, algebra, semiprime ▫$\ast$▫-ring, ▫$H^\ast$▫-algebra, Jordan triple ▫$(\alpha, \beta)^\ast$▫-derivation, generalized Jordan triple ▫$(\alpha, \beta)^\ast$▫-derivation, Jordan triple left ▫$\alpha^\ast$▫-centralizer
Published in RUP: 15.10.2013; Views: 6652; Downloads: 90
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