1. Effects of physiotherapeutic interventions for reducing arthrogenic muscle inhibition in chronic ankle instability : a systematic reviewDanijela Bec, Špela Skubic, Žiga Kozinc, 2025, original scientific article Abstract: Background Chronic ankle instability (CAI) is characterized by recurrent ankle sprains and neuromuscular deficits, including arthrogenic muscle inhibition (AMI), which impairs motor control. Physiotherapeutic interventions targeting neural excitability may help mitigate AMI and improve function. Objective To evaluate the effectiveness of physiotherapeutic interventions in modulating neural excitability and reducing AMI in CAI. Methods A systematic search of six databases identified studies examining the effects of physiotherapy interventions on spinal (H-waves/M-waves (H/M) ratio) and corticospinal excitability (transcranial magnetic stimulation (TMS) outcomes) in CAI. Quality was assessed using the PEDro scale. Results Thirteen studies investigated proprioceptive training, manual therapy, taping, cryotherapy, anodal transcranial direct current stimulation (atDCS), electrotherapy, and dry needling. Prolonged balance training, cryotherapy, and atDCS showed the most consistent effects. Conclusion atDCS, manual therapy, cryotherapy, electrotherapy and balance training may help reduce AMI in CAI, but further studies with larger samples and long-term follow-ups are needed.
Keywords: rehabilitation, physical therapy, ankle instability, arthrogenic inhibition
Published in RUP: 23.02.2026; Views: 458; Downloads: 7
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2. Role of music therapy in the development of language skills in children with autism spectrum disorder : a systematic literature reviewLucija Mlakar, Vesna Posavčević, 2026, review article Abstract: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition that typically emerges in early childhood, marked by difficulties in communication, social interaction, behaviour, and emotional regulation. Despite these challenges, many children with ASD demonstrate exceptional musical abilities, making music a powerful medium for enhancing self-expression, fostering social bonds, and supporting neurological development crucial for speech and social skills. Historically, minimally verbal children with ASD were often excluded from research due to the difficulty of assessment using standardised tools; however, recent advancements have enabled more inclusive studies. Over the past decade, naturalistic approaches have gained prominence, with music therapy emerging as a particularly promising intervention. A systematic literature review, based on original research sourced from PubMed, Sage, and ScienceDirect, examined six studies involving children aged two to twelve years with minimal verbal abilities and a clinical diagnosis of autism. These studies consistently found that music therapy significantly supports the development of language and social communication skills, while also enhancing fronto-temporal brain connectivity. The review contributes valuable insights into the current state of research, underscores the importance of early intervention and parental involvement, and lays the groundwork for further exploration into the role of music therapy in language development for children with ASD.
Keywords: autism spectrum disorder, children, minimal language abilities, social communication, fronto-temporal brain connectivity, music therapy, non-music therapy
Published in RUP: 28.01.2026; Views: 678; Downloads: 21
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3. Pomen fiziološke sinhronije za psihoterapevtski izid : magistrska nalogaClarisa Kuzma, 2024, master's thesis Keywords: physiological synchrony, dyads, interpersonal synchrony, cardiac activity, heart rate, therapy session, psychotherapy, therapy outcomes
Published in RUP: 09.07.2024; Views: 1535; Downloads: 57
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4. Transkranialna magnetna stimulacija (TMS) za terapevtske namene : zaključna nalogaKristjan Bajec, 2018, undergraduate thesis Keywords: TMS, rTMS, depresija, parametri stimulacije, efektivnost terapije, možganska aktivnost, TMS, rTMS, depression, stimulation parameters, therapy effectiveness, brain activity
Published in RUP: 17.04.2018; Views: 9675; Downloads: 106
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5. A novel device to preserve physical activities of daily living in healthy older peopleWolfram Haslinger, Lisa Müller, Nejc Šarabon, Christian Raschner, Helmut Kern, Stefan Loefler, 2015, original scientific article Abstract: Objective: To determine the effectiveness of exercise in improving sensorimotor function and functional performance as crucial part of activities of daily living in healthy older adults. Design: RCT. Setting: Laboratory. Participants: 39 subjects (M = 71.8 years, range: 61%89 years). Intervention: Task oriented visual feedback balance training. Primary outcome measure: Timed up & go (TUG). Secondary outcome measures: Chair stand test (CST), self-paced walk test, maximum isometric torque, quiet stand posturography and dynamic balance (DB). Results: Post intervention comparison of the treatment group (TG) and control group (CG) showed better TUG (p < .01), CST (p < .001) and DB (p < .025) for the TG. Pre%post intervention comparison of the TG showed better clinically relevant outcomes in TUG (p < .001), CST (p < .001) and DB (p < .001). Conclusion: Active driven visual feedback balance training is effective in improving functional performance and dynamic balance in older adults.
Keywords: posturalno ravnotežje, gibalna terapija, staranje, funkcionalna sposobnost, postural balance, exercise therapy, ageing, functional performance
Published in RUP: 03.04.2017; Views: 5601; Downloads: 217
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6. Endoglin (CD105) silencing mediated by shRNA under the control of Endothelin-1 promoter for targeted gene therapy of MelanomaNataša Tešić, Urška Kamenšek, Gregor Serša, Simona Kranjc Brezar, Monika Savarin, Urša Lampreht Tratar, Véronique Préat, Gaëlle Vandermeulen, Miha Butinar, Boris Turk, Maja Čemažar, 2015, original scientific article Abstract: Endoglin (CD105), a transforming growth factor (TGF)-% coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a eukaryotic expression plasmid encoding the shRNA molecules against CD105 under the control of endothelin-1 promoter and to evaluate its therapeutic potential both in vitro in murine B16F10-luc melanoma and SVEC4-10 endothelial cells and in vivo in mice bearing highly metastatic B16F10-luc tumors. Plasmid encoding shRNA against CD105 under the control of the constitutive U6 promoter was used as a control. We demonstrated the antiproliferative and antiangiogenic effects of both plasmids in SVEC4-10 cells, as well as a moderate antitumor and pronounced antimetastatic effect in B16F10-luc tumors in vivo. Our results provide evidence that targeting melanoma with shRNA molecules against CD105 under the control of endothelin-1 promoter is a feasible and effective treatment, especially for the reduction of metastatic spread.
Keywords: melanoma, electroporation, endoglin (CD105), endothelin-1, gene therapy
Published in RUP: 14.10.2015; Views: 6356; Downloads: 136
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