1. Disease severity affects knee range of motion but not strength deficits in knee osteoarthritis : a systematic review and meta-analysisManca Zupančič Opara, Nejc Šarabon, 2026, review article Abstract: Objectives: To compare knee range of motion and muscle strength between individuals with symptomatic knee osteoarthritis and healthy controls, and to assess how Kellgren–Lawrence grade and measurement protocols affect these outcomes.Methods: A systematic search of PubMed, Scopus, and Web of Science identified studies comparing knee flexion/extension range of motion or flexor/extensor strength between patients with knee osteoarthritis and controls. Risk of bias was assessed with Joanna Briggs Institute tools. Pooled mean and standardized mean differences with 95% confidence intervals were calculated using random-effects meta-analyses.Results: Thirty studies were included. Compared with healthy controls, individuals with knee osteoarthritis showed significantly reduced knee flexion [MD = 16.30°, 95%CI (11.40, 21.21)] and extension [MD = 4.25°, 95%CI (2.30, 6.19)], with greater flexion loss in advanced KL grades. Knee osteoarthritis participants also demonstrated significantly lower strength across all contraction types: isometric [extensors: SMD = 0.86, 95%CI (0.57, 1.14); flexors: SMD = 0.52, 95%CI (0.30, 0.74)], concentric [extensors: SMD = 1.07, 95%CI (0.65, 1.50); flexors: SMD = 0.77, 95%CI (0.43, 1.12)], and eccentric extensor strength. Strength deficits were consistent across Kellgren–Lawrence grades, knee joint angles, and angular velocities during testing.Conclusions: Individuals with symptomatic knee osteoarthritis present with marked reductions in knee range of motion and strength. While range of motion impairments worsen with disease severity, strength deficits are stable across Kellgren–Lawrence grades and measurement protocols. Given the very low to low certainty of evidence, results should be interpreted with caution. 1 Introduction
Keywords: osteoarthritis, knee, arthritis, risk factors, rehabilitation
Published in RUP: 18.02.2026; Views: 358; Downloads: 0
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2. Identifying risk factors for sarcopenia using machine learning : insights from multimodal dataFelicita Urzi, Domen Šoberl, Ornella Caputo, Marco Vincenzo Narici, 2025, original scientific article Abstract: Purpose This study aims to identify key risk factors for sarcopenia using machine learning models, leveraging anthropomet- ric, biochemical, functional, nutritional, and genetic data. By developing predictive models, the research seeks to improve early detection, enhance diagnostic accuracy, and facilitate personalized interventions for individuals at risk of sarcopenia. Methods We analysed multimodal data from 484 older adults. Two scenarios: Set-a (including SARC–CalF, excluding SARC-F) and Set-b (including SARC-F, excluding SARC–CalF) were applied in a three-stage modeling process with progressively reduced features and optimized predictive performance using machine learning models. Key predictors were ranked using SHAP values, and model performance was evaluated using AUC, accuracy, sensitivity, and specificity. Internal validation and DeLong’s test were applied to assess robustness and statistical differences. Results The most predictive risk factors included functional measures (chair stand, gait speed), nutritional indicators (pro- tein, folate, copper, vitamin B7), clinical conditions (diabetes, comorbidities, low-density lipoprotein (LDL)), and anthro- pometric markers (body mass index (BMI), calf circumference). Genetic features also contributed to risk stratification. The best-performing model Set-b (with screening test SARC-F) achieved an AUC of 0.951 and an accuracy of 93.62%. While SARC–CalF showed higher individual feature importance, the model achieved an AUC of 0.945 and accuracy of 92.2%. Conclusions This study highlights that traditional sarcopenia screening can be enhanced by capturing complex interplay of functional, nutritional, clinical, and genetic factors, offering clinicians a more accurate and tailored tool for early detec- tion and risk stratification. Future research should focus on validating these models in larger, independent, and longitudinal cohorts to assess their predictive utility across diverse populations and over time.
Keywords: genetics, nutrition, risk factors, sarcopenia
Published in RUP: 23.07.2025; Views: 963; Downloads: 15
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8. Risk factors of suicide death based on psychological sutopsy method; a case-control studyNafee Rasouli, Seyed Kazem Malakouti, Mohsen Rezaeian Rezaeian, Seyed Mehdi Saberi, Marzieh Molavi Nojomi, Diego De Leo, Abbas Ramezani-Farani, 2019, original scientific article Keywords: suicide, risk factors, mental disorders, depression, psychological autopsy
Published in RUP: 11.02.2020; Views: 9960; Downloads: 96
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9. Seasonal variations in human toxoplasma infection in SerbiaBranko Bobić, Ivana Klun, Aleksandra Nikolić, Marija Vujanić, Tijana Živković, Vladimir Ivović, Olgica Djurković-Djaković, 2010, original scientific article Keywords: Toxoplasmosis, acute infections, risk factors, seasonality, Serbia
Published in RUP: 15.10.2015; Views: 4723; Downloads: 145
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10. Suicide and euthanasia in late lifeDiego De Leo, Kym Spathonis, 2003, review article Keywords: samomor s pomočjo, starostniki, evtanazija, samomor, dejavniki tveganja za samomor, transkulturne primerjave, assisted suicide, elderly, euthanasia, risk factors for suicide, transcultural comparisons
Published in RUP: 15.10.2015; Views: 5939; Downloads: 138
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