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In silico analysis of phages-nanogen interplay : human gastrointestinal tract microbiota dynamics and clinical perspectivesIhab Malat,
Michel Drancourt,
B. Henrissat,
Ghiles Grine, 2026, izvirni znanstveni članek
Opis: Digestive tract nanoarchaea Nanopusillus massiliensis and Candidatus Nanopusillus phoceensis form symbiotic nanogens with residing methanogens Methanobrevibacter oralis and Methanobrevibacter smithii, preventing their translocation by unknown mechanisms. We found that 0.45% of M. oralis YH nanogen genome encoding 18 proteins and 1.12% of M. smithii KB11 nanogen genome encoding 32 proteins were of Caudoviricetes and NAV1 origin. In block encoded glycosyltransferase and S-adenosyl-methionine-dependent methyltransferase confer nanogens (but not methanogens) a capacity in cell wall glycosylation. This hypothetical deduced cell wall glycosylation could prevent pseudomurein endo-isopeptidase-mediated interactions of nanogens with digestive tract virome and further nanogen translocation. These observations renew understanding of methanogen and nanogen-associated physiology and pathologies in the digestive tract and beyond.
Ključne besede: Archaeal virome, Methanogens, CRISPR-Spacers, Caudoviricetes, Human microbiome, Microbial diversity, Mobile genetic elements, Nanoarchaea, Nanogen, Methanobrevibacter smithii, Methanobrevibacter oralis
Objavljeno v RUP: 18.06.2026; Ogledov: 242; Prenosov: 8
Celotno besedilo (4,42 MB)
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