1. The impact of hormonal contraceptives on skeletal muscle hypertrophyNevena Markov, Matevž Arčon, 2025, izvirni znanstveni članek Opis: Female reproductive hormones such as progesterone and estrogen play an important role in the body as they orchestrate functions of numerous cells including skeletal muscle cells. Onset of menses marks the beginning of reproductive life, whereas menopause marks its cessation. We distinguish three phases of the 28-day menstrual cycle namely follicular, ovulatory and luteal phases. The follicular phase is characterised by marked increases in estrogen, which triggers ovulation. During this phase, estrogen peaks, whereas progesterone levels are low. Following ovulation, the luteal phase commences marked by high progesterone levels and reduced estrogen. Indeed, these periodic fluctuations in reproductive hormones may affect rates of muscle protein synthesis and hence hinder sought adaptations such as skeletal muscle hypertrophy in female athletes. With the introduction of hormonal contraceptives, female athletes were able to have ameliorate the negative effects of the menstrual cycle by reducing menstrual cramping and bleeding. Hormonal contraceptives are constituted of a single or multiple synthetic hormones namely estrogen and progestin. Nevertheless, the impact of hormonal contraceptives on skeletal muscle hypertrophy remains elusive. In this review, we aim to present the potential implications of hormonal contraceptives on skeletal muscle hypertrophy.
Ključne besede: hormonal contraceptives, estrogen, progesterone, muscle hypertrophy, menstrual cycle, resistance training
Objavljeno v RUP: 07.01.2026; Ogledov: 153; Prenosov: 13
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2. The history, theory and practice of restricted blood flow resistance training (RBFRT/KAATSU)Armin Paravlić, Stefan Đorđević, Raid Mekić, Adem Mavrić, 2015, objavljeni znanstveni prispevek na konferenci Ključne besede: KAATSU, RBFRT, restricted blood flow, occlusion, resistance training, strength, muscle mass, hypertrophy, effects
Objavljeno v RUP: 08.08.2016; Ogledov: 6742; Prenosov: 57
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3. Costamere remodeling with muscle loading and unloading in healthy young menRuowei Li, Marco Vincenzo Narici, Robert M. Erskine, Olivier Seynnes, Joern Rittweger, Rado Pišot, Boštjan Šimunič, M. Flück, 2013, izvirni znanstveni članek Ključne besede: costamere, atrophy, focal adhesion kinase, hypertrophy, physical inactivity, bed rest, skeletal muscle, myofibril, vinculin
Objavljeno v RUP: 15.10.2013; Ogledov: 5552; Prenosov: 161
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4. Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance trainingDesy Salvadego, R. Domenis, Stefano Lazzer, Simone Porcelli, Joern Rittweger, Giovanna Rizzo, I. Mavelli, Boštjan Šimunič, Rado Pišot, Bruno Grassi, 2013, izvirni znanstveni članek Opis: Oxidative function during exercise was evaluated in 11 young athletes with marked skeletal muscle hypertrophy induced by long-term resistance training (RTA, body mass 102.67.3 kg, meanSD) and 11 controls (CTRL, body mass 77.86.0). Pulmonary O2 uptake (V'O2) and vastus lateralis muscle fractional O2 extraction (by near-infrared spectroscopy) were determined during an incremental cycle ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers obtained by biopsy. Quadriceps femoris muscle cross sectional area, volume (determined by magnetic resonance imaging) and strength were greater in RTA vs. CTRL (by ~40%, ~33% and ~20%, respectively). V'O2peak during CE was higher in RTA vs. CTRL (4.050.64 L min-1 vs. 3.560.30); no difference between groups was observed during KE. The O2 cost of CE exercise was not different between groups. When divided per muscle mass (for CE) or quadriceps muscle mass (for KE) V'O2peak was lower (by 15-20%) in RTA vs. CTRL. Vastus lateralis fractional O2 extraction was lower in RTA vs. CTRL at all work rates, both during CE and KE. RTA had higher ADP-stimulated mitochondrial respiration (56.723.7 pmolO2s-1mg-1 ww) vs. CTRL (35.710.2), and a tighter coupling of oxidative phosphorylation. In RTA the greater muscle mass and maximal force, and the enhanced mitochondrial respiration seem to compensate for the hypertrophy-induced impaired peripheral O2 diffusion. The net results are an enhanced whole body oxidative function at peak exercise, and unchanged efficiency and O2 cost at submaximal exercise, despite a much greater body mass
Ključne besede: skeletal muscle, hypertrophy, mitochondrial respiration, oxidative metabolism, exercise
Objavljeno v RUP: 15.10.2013; Ogledov: 6505; Prenosov: 168
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