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High prevalence of probable sarcopenia and its associations with nutrition, cognitive, and physical function in hospitalized patients with Alzheimer’s clinical syndrome : a cross-sectional study
Vesna Simič, Nina Mohorko, Polona Rus Prelog, 2026, izvirni znanstveni članek

Opis: Background: Probable sarcopenia, indicated by low handgrip strength, is a prevalent condition among hospitalized older adults and may reflect broader functional and nutritional decline. Methods: We examined differences in nutritional, functional, and cognitive status between Alzheimer’s clinical syndrome (ACS) patients with probable sarcopenia and those without sarcopenia. A cross-sectional analysis was conducted on 194 hospitalized older adults with ACS. Probable sarcopenia was defined using European Working Group on Sarcopenia in Older People (EWGSOP2) handgrip strength thresholds. Results: Patients with probable sarcopenia (n = 137) had significantly lower Mini-Mental State Examination (MMSE) scores, Geriatric Nutritional Risk Index (GNRI), albumin, hemoglobin, and gait speed compared to those without. After age and sex adjustment, MMSE (p = 0.023), GNRI (p = 0.002), hemoglobin (p = 0.022), albumin (p = 0.003), and gait speed (p < 0.001) remained significantly different. In the sex- and age-adjusted multivariable model (adjusted R2 = 0.442), higher nutritional risk (β = 0.26, p = < 0.001), lower MMSE scores (β = 0.17, p = 0.029), polypharmacy (β = −4.20, p = 0.002), and slower gait speed (β = 4.12, p = 0.010) were associated with reduced handgrip strength. In the multivariable binary logistic regression model (adjusted for age and sex), moderate or high nutritional risk and slow gait speed emerged as independent predictors of probable sarcopenia, with OR 5.14 (95% CI 1.34–19.75; p = 0.017) and OR 3.13 (95% CI 1.30–7.52; p = 0.011), respectively. Conclusions: Probable sarcopenia in hospitalized older adults with ACS is highly prevalent and is associated with higher nutritional risk, poorer cognitive and physical function, and polypharmacy; its early recognition may help to guide more targeted nutritional and functional interventions.
Ključne besede: sarcopenia, muscle strength, Alzheimer’s disease, cognitive function, gait speed, nutrition risk
Objavljeno v RUP: 25.01.2026; Ogledov: 550; Prenosov: 4
.pdf Celotno besedilo (653,67 KB)
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2.
Effects of different lifting strategies during resistance training on lower body function in untrained adult women : a comparison between 6-weeks of 10% velocity loss and standard resistance training
Matic Sašek, Hana Golob, Nejc Šarabon, 2026, izvirni znanstveni članek

Opis: Introduction: This study investigated whether velocity-based resistance training provides additional benefits to lower limb performance compared to standard exercise execution. Methods: Twenty untrained adult women (37–55 years) were randomly assigned to two resistance training groups to perform resistance training with three sets of four lower body exercises per week for 6 weeks. The number of repetitions and lifting velocity differed between the groups. One group performed lower body exercises with maximal intent and a 10% velocity loss threshold termination (VB10%; n = 10), while the other group performed 10 repetitions at a standard 1:2 s concentric:eccentric tempo (STD; n = 10). The number of repetitions was recorded during the sessions. Before and after the intervention, power, muscular endurance and dynamic stability of the lower limbs were assessed using the mean propulsive velocity (MPV) and power (MPP) at 70% one-repetition maximum in the squat and deadlift, the Y-balance test (YBT) and the 30-second sit-to-stand test (STS), respectively. A two-way analysis of variance was used to assess the effects of time, group, and their interaction. Results: The difference between 10 repetitions in the STD and repetitions in the VB10% was assessed using a one-sample t-test. Both groups significantly improved MPP, MPV, YBT and STS [mean difference (MD) ≥5.4%; effect size (ES) ≥0.6]. Although 2.5–2.7 less repetitions were performed in VB10%, the improvements in MPP and MPV were slightly greater (ES ≥ 1.2 vs. ≥ 0.8). Conversely, STS and YBT improved more in STD (ES ≥ 0.4 vs. ≥ 1.0). Discussion: Regardless of the lifting method used, the training intervention improved lower limb power, muscular endurance and dynamic stability, indicating that resistance training is an effective strategy for enhancing these capacities in untrained adult women. Using 10% threshold may be a more time-efficient strategy for improving lower-limb power in this population and could represent a promising approach for mitigating early declines in power over time.
Ključne besede: adult women, dynapenia, muscle performance, power, powerpenia, resistance training, strength, velocity loss
Objavljeno v RUP: 14.01.2026; Ogledov: 671; Prenosov: 9
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