Iskanje po repozitoriju

Ključne besede: struvite, hizostoma pulmo, biotechnological potential, jellyfish, gelatinous plankton, environmental noise
Objavljeno v RUP: 15.10.2025; Ogledov: 579; Prenosov: 10
Celotno besedilo (1,76 MB)

Ključne besede: gelatinous plankton, Mnemiopsis leidyi, biodiversity, northern Adriatic, daily activity, environmental noise
Objavljeno v RUP: 14.10.2025; Ogledov: 570; Prenosov: 14
Celotno besedilo (2,40 MB)

Opis: The number of prediction models proposed in the biomedical literature has been growing year on year. In the last few years there has been an increasing attention to the changes occurring in the prediction modeling landscape. It is suggested that machine learning techniques are becoming more popular to develop prediction models to exploit complex data structures, higher-dimensional predictor spaces, very large number of participants, heterogeneous subgroups, with the ability to capture higher-order interactions. We examine the changes in modelling practices by investigating a selection of systematic reviews on prediction models published in the biomedical literature. We selected systematic reviews published between 2020 and 2022 which included at least 50 prediction models. Information was extracted guided by the CHARMS checklist. Time trends were explored using the models published since 2005. We identified 8 reviews, which included 1448 prediction models published in 887 papers. The average number of study participants and outcome events increased considerably between 2015 and 2019 but remained stable afterwards. The number of candidate and final predictors did not noticeably increase over the study period, with a few recent studies using very large numbers of predictors. Internal validation and reporting of discrimination measures became more common, but assessing calibration and carrying out external validation were less common. Information about missing values was not reported in about half of the papers, however the use of imputation methods increased. There was no sign of an increase in using of machine learning methods. Overall, most of the findings were heterogeneous across reviews. Our findings indicate that changes in the prediction modeling landscape in biomedicine are smaller than expected and that poor reporting is still common; adherence to well established best practice recommendations from the traditional biostatistics literature is still needed. For machine learning best practice recommendations are still missing, whereas such recommendations are available in the traditional biostatistics literature, but adherence is still inadequate.
Ključne besede: predictive model, medicine, changes
Objavljeno v RUP: 14.10.2025; Ogledov: 423; Prenosov: 8
Celotno besedilo (6,00 MB)
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Opis: The aim was to evaluate the effectiveness of semen cryopreservation and oocyte vitrification in roe deer as a potential method of gamete preservation for endangered deer species. Sperm were isolated from the cauda epididymis of fourteen bucks (n = 14). The motility measure (CASA) and morphology of fresh semen (FS) and frozen–thawed semen (TS) were compared. A hyaluronic binding assay was used to distinguish between mature FS spermatozoa expressing hyaluronan receptors and immature FS lacking these receptors, and the mitochondrial membrane potential (MMP) in TS was determined (flow cytometry). A Sperm–Hyaluronan Binding Assay (HBA) showed a viability rate of 61.9% in FS and 78.2% in TS. Oocytes received from eight does (n = 8) underwent a viability test and vitrification, and fresh oocytes from the other eight does (n = 8) were fertilized with TS and embryos were cultured until the blastocyst stage. The number of isolated oocytes, cumulus–oocyte complexes (COCs), cleaved embryos, and expanded blastocysts was evaluated. Higher percentages of morphological factors (acrosome, head, midpiece, and tail shape) were observed in FS compared to TS, whereas the motility and progressive movement were greater in TS (p ≤ 0.001). The viability was 50.5% and MMP was 40.6% in TS. A total of 311 oocytes were collected and from 150 COCs and 125 blastocysts developed. The viability of thawed oocytes after vitrification was 81%. The viability of vitrified oocytes and cryopreserved sperm confirmed the effectiveness of freezing protocols and highlights the potential for their implementation in other deer species.
Ključne besede: roe deer, semen, oocytes, fertilization
Objavljeno v RUP: 13.10.2025; Ogledov: 464; Prenosov: 14
Celotno besedilo (1,10 MB)
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Ključne besede: vmesnik, Cognionics, EEG, naprava 10-20, Matlab, diplomske naloge
Objavljeno v RUP: 13.10.2025; Ogledov: 556; Prenosov: 18
Celotno besedilo (1,41 MB)