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68. Radiation-induced impairment of skeletal muscle regenerationMaja Čemažar, Mihaela Jurdana, 2025, pregledni znanstveni članek Opis: Background. Radiotherapy is a cornerstone of treatment for various cancers, but often causes collateral damage to surrounding healthy tissue, including skeletal muscle. Ionizing radiation leads to oxidative stress and inflammation, which impairs the regenerative capacity of muscle tissue. Irradiation reduces the number and functionality of satellite cells and disrupts the tightly regulated processes of myogenesis and tissue remodelling. In addition, irradiation alters the muscle microenvironment by promoting fibrosis and vascular damage, which further impedes effective regenera-tion. Cytokine signalling pathways are also dysregulated following irradiation, contributing to impaired activation and differentiation of satellite cells. Conclusions. There is evidence that factors such as melatonin and growth factors can improve muscle regenera-tion. Understanding the molecular and cellular mechanisms underlying the impairment of muscle regeneration after radiotherapy is crucial for the development of targeted strategies to mitigate side effects and improve patients’ qual-ity of life. Overall, the preservation and restoration of muscle function in irradiated tissue remains a critical challenge that requires multidisciplinary approaches
Ključne besede: skeletal muscle, radiotherapy, muscle regeneration, melatonine
Objavljeno v RUP: 11.09.2025; Ogledov: 371; Prenosov: 1
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69. Enhancing crisis response efficiency through ICT : a Delphi study on operational and decision-making improvements in mass casualty incidentsPrimož Režek, Boštjan Žvanut, 2025, izvirni znanstveni članek Opis: The potential of information and communication technology (ICT) to improve coordination and decision-making during the training and operational phases of mass casualty incidents (MCIs) has not yet been sufficiently explored. This three-round Delphi study investigates whether ICT use in MCIs can enhance decision-making and increase victim survival rates. The study was conducted from 10 February to 20 September 2024, with 25 international experts from academia, clinical practice, and health informatics. The results were summarised using a SWOT analysis, confirming ICT's perceived potential in MCI management. The analysis revealed a critical asymmetry: while the strengths and opportunities were mainly associated with technical factors (e.g. the effectiveness of drones, global positioning systems, artificial intelligence, dashboards, and virtual and augmented reality to improve the cost-effectiveness of training), weaknesses and threats were mainly social and organisational. These included a lack of standardisation and interoperability, limited ICT-supported training, infrastructure and cybersecurity gaps, resistance to change, legal constraints, underfunding, low technological readiness, and scepticism about the cost-effectiveness of ICT in real-world MCI contexts. Our findings highlight the gap between technological readiness and implementation challenges, suggesting that ICT innovation alone is insufficient without supportive governance, infrastructure, and stakeholder engagement. As the first Delphi study of its kind, it provides a strategic foundation for evidence-based ICT integration in training and operational MCI responses. The findings provide clear priorities for future policy development and empirical validation, emphasising the need to address persistent non-technical barriers to realise ICT’s full potential in crisis management.
Ključne besede: mass casualty incidents (MCI), information and communication technology (ICT), artificial intelligence (AI), drones, electronic triage systems, delphi study, SWOT analysis
Objavljeno v RUP: 08.09.2025; Ogledov: 520; Prenosov: 7
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70. Curvilinear sprint acceleration-speed profile in youth soccer players is constrained by tighter radii and sprinting side dominance : aAžbe Ribič, Darjan Smajla, Oskar Cvjetičanin, Matic Sašek, 2025, izvirni znanstveni članek Opis: This study investigated how the acceleration-speed profile (ASP) of the weaker and stronger side changes at different radii. Twenty male youth soccer players completed 30 m linear and curvilinear sprints (12.15, 11.15, 9.15, 7.15, and 6.15 m radius) in three training sessions. Sprint speed and acceleration over time and distance were recorded using a GNSS device. The maximum theoretical speed (S0), the acceleration (A0), slope of the ASP (ASslope), the area under the ASslope (ASParea), the acceleration at a sprint speed of 3 m/s (A3), and the curvilinear sprint deficit (ASPdeficit) of the individual sprints were analyzed. The effects of side, radius, and their interaction were evaluated with 2 × 5 ANOVA and the post hoc tests. A significant effect of radius and side was observed for all variables (F ≥ 3.50, p ≤ 0.037, η2 ≥ 0.15). The ASParea and S0 decreased at tighter radii. The A3 and A0 remained relatively unchanged, resulting in a steeper ASslope, and a larger ASPdeficit. At the same radius, the weaker side CS had a smaller ASParea, S0, A3, and a larger ASPdeficit. The ASP of the curvilinear sprint in youth soccer players is side-dependent at both ends (acceleration and top speed), while radii mainly affect late acceleration and top speed performance. These observations should be considered when adapting soccer players’ sprint training and monitoring external load based on acceleration.
Ključne besede: curvilinear sprint, acceleration-speed profile, sprint performance, soccer
Objavljeno v RUP: 08.09.2025; Ogledov: 477; Prenosov: 7
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