1. Polyphenolic composition, genetic profile and in vitro antioxidant and cytotoxic activities of artichoke varieties “Strunjanska articoka”, “Romanesco” and "Violetto di Romagna"Katja Kramberger, Alenka Baruca Arbeiter, Ana Petelin, Petra Gabrovšek, Nemanja Teslić, Saša Kenig, Aleksandra Mišan, Dunja Bandelj, Alena Stupar, Zala Jenko Pražnikar, 2025, izvirni znanstveni članek Opis: In recent years, artichokes have gained attention as functional foods due to their polyphenol content and health benefits. While Italian varieties have been widely studied, the Slovenian landrace “Strunjanska articoka” remains largely unexplored. This study compared “Strunjanska articoka” with two Italian varieties, “Romanesco” and “Violetto di Romagna”, assessing genetic profiles, chemical composition, antioxidant activity, and effects on lipid accumulation. The genetic analysis confirmed the uniqueness and clear differentiation of the landrace “Strunjanska articoka” from the two commercial varieties. Analysing the profiles of phenolic compounds in the leaf extracts of these morphologically different artichoke varieties underlines their unique phytochemical composition, which translates into different health benefits. “Romanesco” showed the highest free radical scavenging activity (EC50 = 100 µg/mL), followed by “Strunjanska articoka” (EC50 = 143 µg/mL), and “Violetto di Romagna” (EC50 = 160 µg/mL). Importantly, “Strunjanska articoka” demonstrated superior cytoprotective effects against oxidative stress in HepG2 and CCD112CoN cells. It also reduced lipid accumulation in HepG2 cells, along with “Violetto di Romagna,” whereas “Romanesco” did not. These findings justify further investigation into the potential therapeutic effects of “Strunjanska articoka” and support the rationale for its cultivation.
Ključne besede: artichoke leaf extracts, phenolic compounds, antioxidative potential, lipid accumulation
Objavljeno v RUP: 06.12.2025; Ogledov: 44; Prenosov: 0
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2. The effect of gamification-based exercises on footA systematic review and meta-analysis : a posture in children and adolescents with flatfoot:Ebrahim Ebrahimi, Rahman Sheikhhoseini, Žiga Kozinc, Seyed Alihossein Nourbakhsh, 2025, pregledni znanstveni članek Opis: BackgroundGamification has emerged as a novel approach in rehabilitation. This systematic review and meta-analysis aimed to evaluate the effectiveness of gamification-based exercises on foot posture in children and adolescents with flatfoot. MethodsA systematic review and meta-analysis were conducted in accordance with PRISMA guidelines, utilizing the PubMed, Scopus, Web of Science, and Google Scholar databases to search for original and peer-reviewed articles with selected keywords from inception to July 2025. The quality of the included studies was assessed using the Joanna Briggs Institute checklist. Statistical analysis was conducted with Comprehensive Meta-Analysis software version 3. To evaluate data heterogeneity, the Q-test and I2 statistic were applied. Egger’s test was used to assess publication bias. ResultsAfter searching the mentioned databases, 2160 articles were found. Finally, seven articles were included in the current review. It was shown that gamification-based exercise had a significant effect, leading to a reduction in navicular drop (95% CI = −1.796 to −0.516, p = 0.000) and an increase in balance scores (95% CI = −1.647 to −0.462, p = 0.000), compared to the passive control groups that did not receive any intervention. However, no significant differences were seen in the Staheli index (95% CI = −3.298 to 0.023, p = 0.053). High heterogeneity was noted in the navicular drop test (95% CI = −2.412 to −0.603, p = 0.001). Egger’s test indicated no statistically significant publication bias for either navicular drop (p = 0.080) or Staheli index (p = 0.210). ConclusionThe results showed that exercise with gamification may be effective in improving foot alignment in children and adolescents. Specifically, positive effects were evident when using the navicular drop test, whereas no significant changes were detected with the Staheli index. However, interpretation should be made cautiously due to the limited number of studies and lack of age or gender stratification.
Ključne besede: flatfoot, gamification, therapeutic exercise, meta-analysis
Objavljeno v RUP: 04.12.2025; Ogledov: 63; Prenosov: 2
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3. Redox state is similar in subjects following omnivorous, vegan, vegetarian, and low-carbohydrate high-fat dietNives Bogataj Jontez, Karin Šik Novak, Zala Jenko Pražnikar, Ana Petelin, Nina Mohorko, Saša Kenig, 2025, izvirni znanstveni članek Opis: Age-related noncommunicable diseases are a major health burden in developed countries, with oxidative stress being a key contributing factor. This cross-sectional study aimed to test the hypothesis that redox status among 88 participants with a particular interest in nutrition and habitually following 4 popular dietary patterns (vegan, vegetarian, low-carbohydrate high-fat, and omnivorous), is similar, but correlates with diet quality. Dietary intake was assessed using food diaries, and venous blood samples were collected to measure serum total antioxidative capacity (TAC), bilirubin, nicotinamide adenine dinucleotide (NAD⁺)/reduced form of nicotinamide adenine dinucleotide (NADH) ratio, and sirtuin 1 concentration, and the expression of antioxidative enzymes in leukocytes. TAC and the NAD⁺/NADH ratio were higher in the vegan group compared with the vegetarian group, whereas bilirubin concentration was higher in the omnivorous compared with the low-carbohydrate high-fat group. Other differences between the dietary groups were not significant. NAD+/NADH ratio and sirtuin 1 were positively correlated with diet quality, assessed with the Healthy Eating Index. Correlation analysis between dietary variables and redox markers revealed only a few weak to moderate associations. However, a hierarchical regression model including age, gender, and dietary variables explained 19.8% of the variance in TAC, 21.2% of the variance in the NAD⁺/NADH ratio, and 44.3% of the variance in sirtuin 1 concentration. Therefore, in healthy, relatively young participants with appropriate energy intakes, endogenous mechanisms are able to compensate for oxidative stress to a similar extent, regardless of dietary pattern. Nonetheless, overall diet quality and food selection appear to play a meaningful role in redox balance.
Ključne besede: oxidative stress, total antioxidative capacity, sirtuin 1, diet quality
Objavljeno v RUP: 02.12.2025; Ogledov: 84; Prenosov: 2
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5. Joint torque and electromyographic activity during eccentric exercise for hip adductors at different hip flexion anglesJan Marušič, Oskar Cvjetičanin, Nejc Šarabon, 2025, izvirni znanstveni članek Opis: Our objective was to investigate the effects of three hip flexion angles (0°, 45°, and 90°) and leg dominance on peak joint torque, angle at peak torque, and peak electromyographic activity (EMGA) of the adductor longus during bilateral eccentric hip adduction. Sixteen recreationally active participants completed bilateral eccentric contractions at each hip flexion angle using a custom-built dynamometer. The primary outcome measures were peak adduction torque, angle at peak torque, and EMGA of the adductor longus. A 3×2 repeated measures ANOVA was used to assess the effects of hip angle and leg dominance. Hip flexion angle had a significant main effect on peak torque (F(2, 30) = 15.75, p<0.01), with peak torque significantly lower at 90° compared to 0° and 45°. No significant effects were observed for leg dominance or interaction. No significant main effects of hip flexion angle, leg dominance, or their interaction were observed on peak EMGA or peak torque angle. Eccentric hip adduction strength is reduced at 90° of flexion, likely due to mechanical disadvantage, while neural activation remains unchanged. These findings support the use of less flexed positions in eccentric training protocols for adductor strength development or injury prevention.
Ključne besede: adductor longus, eccentric training, injury prevention, strength
Objavljeno v RUP: 19.11.2025; Ogledov: 219; Prenosov: 5
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6. The usefulness of a body shape index in assessing muscle function and strength in older adults hemodialysis patients : aBojan Knap, Boštjan Žvanut, Lucija Brezočnik, Mihaela Jurdana, 2025, izvirni znanstveni članek Opis: Objective: This study investigates the relationship between a new anthropometric measure, the Body Shape Index (ABSI), and body composition and biochemical parameters in hemodialysis patients and, for the first time, the correlation between ABSI and muscle strength and function in these patients. Methods: A cross-sectional study was conducted on a sample of 80 patients who were regularly treated in the hemodialysis unit of a single medical center of the University Hospital of Ljubljana, Slovenia. General anthropometric parameters body mass index (BMI) and ABSI=(WC/(BMI2/3x height½) as well as body composition data (fat mass FM, fat-free mass FFM, fat-free mass index FFMI, skeletal muscle index SMI) were determined in 25 women (aged 74.5 ± 7.5 years) and 55 men (aged 70.1 ± 6.6 years) with overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and obesity (BMI ≥ 30 kg/m2) by bioelectrical impedance analysis (BIA). Muscle strength was determined using a hand grip strength test, while muscle performance was assessed using the sit-to-stand test. Results: ABSI was significantly negatively associated with muscle strength, functional tests and SMI only in men. Based on the median ABSI value (0.090273 m11/6·kg−2/3 in women and 0.090893 m11/6·kg−2/3 in men), women with a higher ABSI had a significantly higher glucose concentration than those with a lower ABSI. Men with a lower ABSI obtained significantly better results in the hand grip test, sit-to-stand test and waist circumference (WC). In conclusion, our findings suggest an inverse association between ABSI and muscle strength and function in male hemodialysis patients, indicating that higher ABSI may reflect poorer physical condition in this population. Further longitudinal studies are needed to explore the clinical significance of this relationship.
Ključne besede: hemodialysis, muscle strenght, sarcopenia
Objavljeno v RUP: 10.11.2025; Ogledov: 237; Prenosov: 6
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