11. How many people die by suicide each year? Not 727,000 : a systematic review and meta-analysis of suicide underreporting across 71 countries over 122 yearsNicola Meda, Ludovica Angelozzi, Matteo Poletto, Angelo Patane, Josephine Zammarrelli, Irene Slongo, Fabio Sambataro, Diego De Leo, 2025, pregledni znanstveni članek Opis: Background: Suicide underreporting undermines accurate public health assessments and resource allocation for suicide prevention. This study aims at synthesizing evidence on suicide underreporting and to estimate a global underreporting rate. Methods: We conducted a PRISMA-compliant systematic review on suicide underreporting, following a pre-registered protocol. A meta-analytical synthesis was also conducted. Quantitative data from individual studies was extracted to provide an overall global estimate of suicide underreporting (42 studies covering 71 countries out of the initial 770 unique studies, spanning 1900–2021). Most studies used retrospective institutional datasets to estimate underreporting through reclassification of undetermined deaths or comparisons across databases. Demographic and geographic disparities were also examined. Results: The 42 studies selected provided some quantitative data on suicide underreporting for general or specific populations. 14 of these studies provided data to be meta-analyzed. The global suicide underreporting rate was estimated to be 17.9% (95% CI: 10.9–28.1%) with large differences between countries with high and low/very low data quality. In this scenario, the last WHO estimates of suicide deaths – corrected for underreporting – would be more than one million (1,000,638; 95% CI: 859,511–1,293,006) and not 727,000 suicides per year. Underreporting was higher in low- and middle-income countries (LMICs) with incomplete death registration systems, such as India and China (34.9%; 95% CI 20.3–53%), while high-income countries exhibited lower rates (11.5%; 95% CI 6.6–19.3%). Contributing factors included stigma, religiosity, limited forensic resources, and inconsistent use of International Classification of Diseases (ICD) codes. Gender and age disparities were notable; Female suicides and those among younger or older individuals were more likely to be misclassified. Discussion: Addressing suicide underreporting requires improving death registration systems globally, particularly in LMICs. Standardizing ICD usage, improving forensic capacity, and reducing stigma are critical steps to ensure accurate data. Heterogeneity, geographical disparities, temporal biases, and invariance of suicide underreporting for countries with low-quality data demand further corroboration of these findings. Ključne besede: misclassification, under-reporting, suicide, global burden, global health estimates Objavljeno v RUP: 18.12.2025; Ogledov: 197; Prenosov: 3
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12. Suicide-related mortality trends in Europe, 2012–2021Marco Zuin, Diego De Leo, 2025, izvirni znanstveni članek Opis: Aims: Updated data regarding the suicide-related mortality trend in Europe remain scant. We assess the age- and sex-specific trends in suicide-related mortality in the European states (EU) between the years 2012 and 2021. Methods: We retrieved data on cause-specific deaths and population numbers by sex for European countries from the publicly available EUROSTAT mortality dataset for the years 2012–2021. This study was chosen because 2012 was the first year with complete uninterrupted suicide mortality data for all EU member states, while 2021 was the most recent year with confirmed estimates in the EUROSTAT database. Suicide-related deaths were identified using the International Classification of Diseases, 10th revision codes X60–X84 and Y870 as the underlying cause of death. We calculated annual trends by assessing the average annual percentage change (AAPC) with corresponding 95% confidence intervals (CIs) using joinpoint regression. Results: During the study period, there were 391,555 suicide-related deaths in Europe (313,835 men and 77,720 women). The age-adjusted mortality rate (AAMR) decreased linearly from 12.3 (95% CI: 12.0 to 12.6) per 100,000 people in 2012 to 10.2 (95% CI: 10.0 to 10.5) per 100,000 people in 2021 [AAPC: −2.3% (95% CI: −2.9 to −1.8); p < 0.001]. This decline was more pronounced among men [AAPC: −2.4% (95% CI: −2.9 to −2.0), p < 0.001] compared to women [AAPC: −1.9% (95% CI: −2.7 to −1.0), p < 0.001] (p for parallelism = 0.003). A more significant decrease was observed in individuals under 65 years compared to older individuals (p for parallelism = 0.001). Some EU subregions and demographic groups showed stagnation in suicide-related mortality rates. Conclusions: Over the past decade, age-adjusted suicide-related mortality has declined in Europe, particularly among males and individuals under 65 years old. However, disparities persist between countries and EU subregions. Ključne besede: suicide, Europe, age, mortality rate, sex, older adults Objavljeno v RUP: 18.12.2025; Ogledov: 202; Prenosov: 2
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13. Revisiting cultural issues in suicide rates : the case of Western countriesDiego De Leo, Mujde Altin, 2025, izvirni znanstveni članek Opis: Suicidal behaviors among different age groups show epidemiological differences between countries. Specifically, suicide rates for the younger populations appear to be lower in Latin-origin countries (such as Italy, Spain, and Portugal) in comparison to other Western countries (especially Anglo-Saxon countries such as Canada, New Zealand, and Australia). The opposite seems to be true for the older population, suggesting a cross- cultural pattern for suicidal behavior in different ages. The current study replicates a study published in 1999 and compares suicide data between 1990 and 1994 with more recent data from the years 2016 and 2020 to investigate the persistence of previously observed trends. Basically, the recent years’ data confirm the patterns evidenced a quarter of a century ago, and substantially confirm the existence of suicide trends embedded with countries’ cultural factors and traditions. This investigation underlines the importance of incorporating anthropology, sociology, ethnography, and geography while studying culture-related patterns in suicide. Ključne besede: suicide trends, cultural factors, Western countries, Latin countries, Anglo-Saxon countries Objavljeno v RUP: 18.12.2025; Ogledov: 142; Prenosov: 2
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14. Methanobrevibacter smithii strain U29 whole genome sequence delineates M. smithii intermediate cell variantsIhab Malat, Vincent Bossi, Michel Drancourt, Ghiles Grine, Raymond Ruimy, 2025, izvirni znanstveni članek Opis: Background Methanobrevibacter smithii (M. smithii), the predominant methanogen in the human digestive tract, plays a key role in methane production. Despite its importance, the genomic diversity of M. smithii is poorly characterised, especially in extra-digestive sites such as the urinary and respiratory tracts, and the blood. Understanding this diversity would help unravel its potential role in human health and diseases. Results We report the genome of M. smithii strain U29, isolated from urine, expanding the known diversity of the species. The M. smithii U29 genome (scaffold level; 1̵822‒124-bp, 1745 protein-coding sequences) lacks Candidatus Nanopusillus sequences, unlike digestive tract strains. Comparative analysis has revealed a high similarity (99.86% ANI) with the reference M. smithii strain ATCC 35,061, although U29 contains 71 unique coding sequences including 12/71 (13 200-bp; 69% of the total extra-material size) with demonstrated Siphoviridae viral ancestry. Accordingly, M. smithii U29 has been identified as an intermediate M. smithii cell variant, exhibiting genomic traits potentially conferring adaptability to the urinary tract. Conclusion This study enhances our understanding of M. smithii genomic diversity and highlights the presence of viral sequences in the urinary tract M. smithii strain U29. These findings open up a hypothesis that viral integration may play a role in M. smithii mucosae colonisation and dynamics, underscoring the need for further investigations into the mechanisms underlying its tissue translocation and potential health implications. Ključne besede: Methanobrevibacter smithii, Archaea, urinary tract, genome, cell variants Objavljeno v RUP: 18.12.2025; Ogledov: 148; Prenosov: 2
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15. Treewidth is NP-complete on cubic graphsHans L. Bodlaender, Édouard Bonnet, Lars Jaffke, Dušan Knop, Paloma T. Lima, Martin Milanič, Sebastian Ordyniak, Sukanya Pandey, Ondřej Suchý, 2025, izvirni znanstveni članek Opis: The concept of avoidable paths in graphs was introduced by Beisegel, Chudnovsky, Gurvich, Milanič, and Servatius in 2019 as a common generalization of avoidable vertices and simplicial paths. In 2020, Bonamy, Defrain, Hatzel, and Thiebaut proved that every graph containing an induced path of order k also contains an avoidable induced path of the same order. They also asked whether one could generalize this result to other avoidable structures, leaving the notion of avoidability up to interpretation. In this paper, we address this question: we specify the concept of avoidability for arbitrary graphs equipped with two terminal vertices. We provide both positive and negative results, some of which are related to a recent work by Chudnovsky, Norin, Seymour, and Turcotte in 2024. We also discuss several open questions. Ključne besede: treewidth, cubic graph, NP'completeness Objavljeno v RUP: 18.12.2025; Ogledov: 160; Prenosov: 0
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16. Qualitative content analysis of COVID-19’s role in suicide attempts leading to hospital careMartina Mravlja, Anthony Pisani R., Annamarie Bailey, Nicola Meda, Alexandre Paim-Diaz, Kristina Zurich, Kenneth Conner, 2025, izvirni znanstveni članek Opis: Introduction: The impact of the COVID-19 pandemic on suicide risk has been documented during the acute phase, but less is known about people who attempted suicide during the post-acute period. This study investigates how adults who attempted suicide during the post-acute pandemic period (2021–2023) understood COVID-19’s role in their attempt. Method: We analyzed interview data from 329 adults (59% female; 41% male), enrolled following a recent suicide attempt between 2021 and 2023. Participants were asked about the general impact of COVID-19 on their lives and then specifically about whether stress related to COVID-19 was a primary reason for their attempt or contributed to their suicidal thoughts. Results: When asked about their recent attempt, 11% of participants identified stress related to COVID-19 as the primary reason for their attempt, and an additional 23% indicated it contributed to their suicidal thoughts. When describing general impacts, participants reported effects across multiple domains: social isolation, physical health concerns, mental health impacts, and economic effects. Discussion: The attribution of suicide attempts to COVID-19-related stress during the post-acute period highlights the extended impact of public health crises on vulnerable individuals. These findings emphasize the need for sustained, integrated medical and mental healthcare following such crises. Ključne besede: suicide, COVID-19, pandemic mental health, loneliness, isolation, healthcare, stress, prevention Objavljeno v RUP: 17.12.2025; Ogledov: 196; Prenosov: 5
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17. Experimental and analytical evaluation of shear capacity of reclaimed timber connections with thermo-mechanically densified wooden dowelsMohammad Derikvand, Donya Bazyar Khoshroodi, 2025, izvirni znanstveni članek Opis: The reuse of reclaimed timber in structural applications is increasingly recognized as a strategy to extend ma- terial life cycles and reduce waste. Particular attention has recently turned to reusing reclaimed timber in adhesive-free laminated products with wooden dowels, where connection performance is critical. The aim of this study was to investigate the mechanical performance of double-shear connections assembled from reclaimed spruce timber using thermo-mechanically densified wooden dowels. The dowels were first evaluated in bending and embedment tests on lamellae made from both reclaimed and virgin spruce timber. The shear capacity of the connections was then evaluated in three layups: two homogeneous (all-reclaimed lamellae and all-virgin spruce lamellae) and one hybrid (reclaimed side lamellae with a central virgin spruce lamella). Analytical predictions were performed based on the draft of the new Eurocode 5, however, with two alternative definitions of dowel bending resistance (ultimate moment Mu and yield moment My), and three alternative definitions of embedment strength (f 0.05d h calculated using the 0.05 d offset method, f Fmax h calculated from Fmax, and f 0.8Fmax h calculated from 0.8 Fmax). The three lamellae layups exhibited relatively similar mean capacities (7.3–8.3 kN). The all-reclaimed connections were on average 13 % stronger than the other assemblies, but this was not statistically significant. Among the model input variants, Mu with f 0.05d h showed the closest agreement with the experimental mean values, while My with f 0.05d h led to more conservative predictions preferable for design. In both cases, excluding outliers from the embedment test results reduced overestimation in the predictions. All other input variants overestimated the shear capacity. Overall, both homogeneous and hybrid connections with reclaimed timber lamellae performed comparably to virgin timber connections and exhibited predictable mechanical behavior. Ključne besede: reclaimed timber, wood densification, structural reuse, embedment strength, dowel connections, European yield model, Eurocode 5 Objavljeno v RUP: 17.12.2025; Ogledov: 190; Prenosov: 3
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18. Computing tree decompositions with small independence numberClément Jean Dallard, Fedor V. Fomin, Petr A. Golovach, Tuukka Korhonen, Martin Milanič, 2026, izvirni znanstveni članek Opis: The independence number of a tree decomposition is the maximum of the independence numbers of the subgraphs induced by its bags. The tree-independence number of a graph is the minimum independence number of a tree decomposition of it. Several NP-hard graph problems, like maximum-weight independent set, can be solved in time n^O(k) if the input n-vertex graph is given together with a tree decomposition of independence number k. Yolov, in SODA 2018, gave an algorithm that, given an n-vertex graph G and an integer k, in time n^O(k^3) either constructs a tree decomposition of G whose independence number is O(k^3) or correctly reports that the tree-independence number of G is larger than k. In this article, we first give an algorithm for computing the tree-independence number with a better approximation ratio and running time and then prove that our algorithm is, in some sense, the best one can hope for. Our second result is that the exact computation of the tree-independence number is para-NP-hard: We show that for every constant k ≥ 4 it is NP-complete to decide whether a given graph has the tree-independence number at most k. Ključne besede: tree-independence number, approximation, parameterized algorithm Objavljeno v RUP: 16.12.2025; Ogledov: 238; Prenosov: 3
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19. Conformality of minimal transversals of maximal cliquesEndre Boros, Vladimir Gurvich, Martin Milanič, Dmitry Tikhanovsky, Yushi Uno, 2026, izvirni znanstveni članek Opis: Given a hypergraph ℋ, the dual hypergraph of ℋis the hypergraph of all minimal transversals of ℋ. A hypergraph is conformal if it is the family of maximal cliques of a graph. In a recent work, Boros, Gurvich, Milanič, and Uno (Journal of Graph Theory, 2025) studied conformality of dual hypergraphs and proved several results related to this property, leading in particular to a polynomial-time algorithm for recognizing graphs in which, for any fixed k, all minimal transversals of maximal cliques have size at most k. In this follow-up work, we provide a novel aspect to the study of graph clique transversals, by considering the dual conformality property from the perspective of graphs. More precisely, we study graphs for which the family of minimal transversals of maximal cliques is conformal. Such graphs are called clique dually conformal (CDC for short). It turns out that the class of CDC graphs is a rich generalization of the class of P4-free graphs. As our main results, we completely completely characterize CDC graphs within the families of triangle-free graphs and split graphs. Both characterizations lead to polynomial-time recognition algorithms. Generalizing the fact that every P4-free graph is CDC, we also show that the class of CDC graphs is closed under substitution, in the strong sense that substituting a graph H for a vertex of a graph G results in a CDC graph if and only if both G and H are CDC. Ključne besede: maximal clique, minimal transversal, conformal hypergraph, triangle-free graph, split graph Objavljeno v RUP: 16.12.2025; Ogledov: 217; Prenosov: 2
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20. Induced minor models : Structural properties and algorithmic consequencesNicolas Bousquet, Clément Jean Dallard, Maël Dumas, Claire Hilaire, Martin Milanič, Anthony Perez, Nicolas Trotignon, 2026, izvirni znanstveni članek Opis: A graph H is an induced minor of G if there exists an induced minor model of H in G, that is, a collection of pairwise disjoint subsets of vertices of G labeled by the vertices of H, each inducing a connected subgraph in G, such that two vertices of H are adjacent if and only if there is an edge in G between the corresponding subsets. In this paper, we investigate structural properties of induced minor models, including bounds on treewidth and chromatic number of the subgraphs induced by minimal induced minor models. As algorithmic applications of our structural results, we make use of recent developments regarding tree-independence number to show that if H is the 4-wheel, the 5-vertex complete graph minus an edge, or a complete bipartite graph K2,q , then there is a polynomial-time algorithm to find in a given graph G an induced minor model of H in G, if there is one. We also develop an alternative polynomial-time algorithm for recognizing graphs that do not contain K2,3 as an induced minor, which revolves around the idea of detecting the induced subgraphs whose presence is forced when the input graph contains K2,3 as an induced minor. It turns out that all these induced subgraphs are Truemper configurations. Ključne besede: induced minor, treewidth, chromatic number, tree-independence number, Truemper configuration Objavljeno v RUP: 16.12.2025; Ogledov: 205; Prenosov: 3
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