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1.
Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer’s disease
Alberto Benussi, Federica Agosta, Alba Rosa Alfano, Antonio Antico, Giuseppe Bellelli, Laura Bonanni, Gabriella Bottini, Marco Bozzali, Ovidio Brignoli, Giuseppe Bruno, Diego De Leo, 2025, pregledni znanstveni članek

Opis: This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient journey in the era of anti-amyloid monoclonal antibodies for Alzheimer’s disease. Emphasizing a multidisciplinary and integrated approach, the document recommends a patient journey that begins with early identification of cognitive impairment by General Practitioners, continues with specialized assessments at Memory and Dementia Centres, and leads, in carefully selected cases, to initiation of anti-amyloid monoclonal antibody therapy. It advocates the rational use of diagnostic tools, including plasma and cerebrospinal fluid biomarkers, advanced neuroimaging (MRI and PET), and genetic profiling (ApoE genotyping), not only to identify eligible patients but also to stratify those requiring alternative care strategies. The paper further defines minimum requirements for the accreditation of prescribing and infusion centres, highlighting the clinical competencies, structural resources, and inter-professional communication protocols necessary to ensure safety and appropriateness. Recognizing both the therapeutic potential and the organizational challenges associated with anti-amyloid monoclonal antibodies, the document aims to guide healthcare policymakers, institutions, and practitioners toward a coordinated reorganization of the diagnostic-therapeutic pathway, ensuring the safe and effective use of these treatments and ultimately improving outcomes and quality of care for individuals with Alzheimer’s disease.
Ključne besede: Alzheimer’s disease, disease-modifying therapies, anti-amyloid monoclonal antibodies, biomarkers, clinical implementation
Objavljeno v RUP: 22.12.2025; Ogledov: 575; Prenosov: 4
.pdf Celotno besedilo (1,22 MB)
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2.
Exploring social interactions on the Adriatic network
Žiga Velkavrh, 2025, izvirni znanstveni članek

Opis: This paper explores social interactions on the Adriatic network consisting of six countries surroundingthe Adriatic Sea. Using game theory, we analyze how three well-known classes of 2x2 strategic games, namely Prisoner’s dilemma, anti-coordination and coordination games, would be played on the Adriatic network. We determine all Nash equilibria, i.e., steady states, and obtain two main results. First, anti-coordination games on the Adriatic network always induce multiple (4, 5, 7 or 12) Nash equilibria that vary with payoffs and may differin efficiency. Second, coordination games on the Adriatic network have only trivial equilibria, unless a specific condition on payoffs is met, in which case two new equilibria emerge. Our findings may be of great interest for policy makers and other scholars interested in maritime pollution control and other water-related problems, as well as biodiversity conservation, as they indicate at which maritime borders (anti)coordination issues and resulting inefficiencies may arise. Knowing that, one may give special attention to the critical maritime borders and take extra care there, thus helping to prevent potential catastrophic events. Finally, our study can also be used for academic purposes, e.g., in classroom, to demonstrate how to perform a complete Nash equilibrium analysis on some real-world network which has a relatively simple structure.
Ključne besede: Adriatic, anti-coordination games, coordination games, game theory, Nash equilibrium, networks, prisoner’s dilemma, spatial games
Objavljeno v RUP: 20.11.2025; Ogledov: 787; Prenosov: 14
.pdf Celotno besedilo (566,03 KB)
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Jordan [tau]-derivations of locally matrix rings
Chen-Lian Chuang, Ajda Fošner, Tsiu Kwen Lee, 2013, izvirni znanstveni članek

Opis: Let ▫$R$▫ be a prime, locally matrix ring of characteristic not 2 and let ▫$Q_{ms}(R)$▫ be the maximal symmetric ring of quotients of ▫$R$▫. Suppose that ▫$\delta \colon R \to Q_{ms}(R)$▫ is a Jordan ▫$\tau$▫-derivation, where ▫$\tau$▫ is an anti-automorphism of $R$. Then there exists ▫$a \in Q_{ms}(R)$▫ such that ▫$\delta(x) = xa - a\tau(x)$▫ for all ▫$x \in R$▫. Let ▫$X$▫ be a Banach space over the field ▫$\mathbb{F}$▫ of real or complex numbers and let ▫$\mathcal{B}(X)$▫ be the algebra of all bounded linear operators on ▫$X$▫. We prove that ▫$Q_{ms}(\mathcal{B}(X)) = \mathcal{B}(X)$▫, which provides the viewpoint of ring theory for some results concerning derivations on the algebra ▫$\mathcal{B}(X)$▫. In particular, all Jordan ▫$\tau$▫-derivations of ▫$\mathcal{B}(X)$▫ are inner if ▫$\dim_{\mathbb{F}} X>1$▫.
Ključne besede: mathematics, algebra, anti-automorphism, locally matrix ring, prime ring, Jordan homomorphism, Jordan ▫$\tau$▫-derivation, Banach space
Objavljeno v RUP: 15.10.2013; Ogledov: 11480; Prenosov: 97
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