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Abstract: Background It remains unclear whether adding time-restricted eating (TRE) to energy restriction (ER) offers additional cardiometabolic benefits, particularly in metabolic hormone regulation, and insulin sensitivity. This per-protocol analysis assessed whether early TRE (eTRE) or late TRE (lTRE), when combined with ER, additionally improves insulin resistance indexes, and cardiovascular and liver biomarkers compared to ER alone. Methods We analysed per-protocol data of 90 participants, 31 from the eTRE with ER (eTRE + ER) group, 28 from the lTRE with ER (lTRE + ER) group and 31 from the ER group. As chronotype-adapted diets have already been shown to produce better outcomes than non-adapted ones and in line with real-life behaviour, randomisation was performed on the basis of the individuals’ chronotype. Anthropometric and biochemical measurements for analysis were taken at baseline, and after first and third month of intervention. The primary outcome was mean change in body mass, while the secondary outcomes were mean changes in glycaemic markers (fasting glucose, fasting insulin), indexes of insulin resistance, cardiovascular and liver markers and metabolic hormones (adiponectin, ghrelin, leptin, leptin/ghrelin ratio). Additionally, participant’s subjective appetite was also assessed at baseline and in third month of the intervention. Results We confirmed that participants who adhered to eTRE + ER for 3 months showed greater improvements in % of fat mass, BMI, and fasting glucose compared to those in the lTRE + ER and/or ER group. These greater reductions in % of the fat mass and BMI were accompanied by more pronounced decreases in leptin levels, with eTRE + ER showing larger leptin reductions than lTRE + ER or ER. Additionally, the eTRE group showed a significantly greater decrease in desire for food and greater reduction in capacity to eat than ER. However, insulin levels, insulin resistance indexes, lipid profiles, adiponectin, ghrelin, visceral fat indexes, and liver enzymes showed similar changes across all groups. Conclusions This analysis showed that eTRE + ER is more effective weight management strategy, while eTRE + ER, lTRE + ER and ER are comparable effective on cardiovascular, liver and insulin resistance markers. Trial registration https://clinicaltrials.gov/study/NCT05730231 (NCT05730231, registered on February 6, 2023).
Keywords: obesity, nutrition, metabolism
Published in RUP: 30.07.2025; Views: 1202; Downloads: 32
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Abstract: Oxidative function during exercise was evaluated in 11 young athletes with marked skeletal muscle hypertrophy induced by long-term resistance training (RTA, body mass 102.67.3 kg, meanSD) and 11 controls (CTRL, body mass 77.86.0). Pulmonary O2 uptake (V'O2) and vastus lateralis muscle fractional O2 extraction (by near-infrared spectroscopy) were determined during an incremental cycle ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers obtained by biopsy. Quadriceps femoris muscle cross sectional area, volume (determined by magnetic resonance imaging) and strength were greater in RTA vs. CTRL (by ~40%, ~33% and ~20%, respectively). V'O2peak during CE was higher in RTA vs. CTRL (4.050.64 L min-1 vs. 3.560.30); no difference between groups was observed during KE. The O2 cost of CE exercise was not different between groups. When divided per muscle mass (for CE) or quadriceps muscle mass (for KE) V'O2peak was lower (by 15-20%) in RTA vs. CTRL. Vastus lateralis fractional O2 extraction was lower in RTA vs. CTRL at all work rates, both during CE and KE. RTA had higher ADP-stimulated mitochondrial respiration (56.723.7 pmolO2s-1mg-1 ww) vs. CTRL (35.710.2), and a tighter coupling of oxidative phosphorylation. In RTA the greater muscle mass and maximal force, and the enhanced mitochondrial respiration seem to compensate for the hypertrophy-induced impaired peripheral O2 diffusion. The net results are an enhanced whole body oxidative function at peak exercise, and unchanged efficiency and O2 cost at submaximal exercise, despite a much greater body mass
Keywords: skeletal muscle, hypertrophy, mitochondrial respiration, oxidative metabolism, exercise
Published in RUP: 15.10.2013; Views: 7072; Downloads: 168
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