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413. Gibanje socialnih skupin v prostoru : analiza obiskanosti gostinskih lokalov (na primeru mesta Koper)Maja Avčin, 2016, diplomsko delo Ključne besede: Koper, socialne skupine, socialna diferenciacija, prostorska diferenciacija, gostinski lokali, življenjski stil, "mrtve točke", diplomska dela Objavljeno v RUP: 10.11.2016; Ogledov: 2876; Prenosov: 83 Celotno besedilo (6,04 MB) |
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416. Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectivenessMaja Čemažar, Vesna Todorović, Janez Ščančar, Urša Lampreht Tratar, Monika Savarin, Urška Kamenšek, Simona Kranjc Brezar, Andrej Cör, Gregor Serša, 2015, izvirni znanstveni članek Opis: Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most suitable for clinical use. Intravenous administration of cisplatin for electrochemotherapy is still not widely accepted in the clinics, presumably due to its lower antitumor effectiveness, but adjuvant therapy by immunomodulatory or vascular-targeting agents could provide a way for its potentiation. Hence, the aim of the present study was to explore the possibility of adjuvant tumour necrosis factor % (TNF-%) therapy to potentiate antitumor effectiveness of electrochemotherapy with intravenous cisplatin administration in murine sarcoma. Materials and methods. In vivo study was designed to evaluate the effect of TNF-% applied before or after the electrochemotherapy and to evaluate the effect of adjuvant TNF-% on electrochemotherapy with different cisplatin doses. Results. A synergistic interaction between TNF-% and electrochemotherapy was observed. Administration of TNF-% before the electrochemotherapy resulted in longer tumour growth delay and increased tumour curability, and was significantly more effective than TNF-% administration after the electrochemotherapy. Tumour analysis revealed increased platinum content in tumours, TNF-% induced blood vessel damage and increased tumour necrosis after combination of TNF-% and electrochemotherapy, indicating an anti-vascular action of TNF-%. In addition, immunomodulatory effect might have contributed to curability rate of the tumours. Conclusion. Adjuvant intratumoural TNF-% therapy synergistically contributes to electrochemotherapy with intravenous cisplatin administration. Due to its potentiation at all doses of cisplatin, the combined treatment is predicted to be effective also in tumours, where the drug concentration is suboptimal or in bigger tumours, where electrochemotherapy with intravenous cisplatin is not expected to be sufficiently effective. Ključne besede: electrochemotherapy, TNF, adjuvant immunotherapy, cisplatin Objavljeno v RUP: 09.08.2016; Ogledov: 5717; Prenosov: 135 Povezava na celotno besedilo |
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418. A complex view of Industry 4.0Vasja Roblek, Maja Meško, Alojz Krapež, 2016, izvirni znanstveni članek Ključne besede: internet, Industry 4.0, internet, internet of things, costumer behavior, Industry 4.0, relationship problems Objavljeno v RUP: 08.08.2016; Ogledov: 3557; Prenosov: 56 Povezava na celotno besedilo |
419. The complexity view on the changes in social and economic environment in 21 centuryVasja Roblek, Zlatka Meško Štok, Maja Meško, 2016, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Ključne besede: informacijska tehnologija, industrija, globalizacija, information technology, industry 4.0, globalization, sharing economy Objavljeno v RUP: 08.08.2016; Ogledov: 3118; Prenosov: 67 Povezava na celotno besedilo |
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