Iskanje po repozitoriju

Opis: This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient journey in the era of anti-amyloid monoclonal antibodies for Alzheimer’s disease. Emphasizing a multidisciplinary and integrated approach, the document recommends a patient journey that begins with early identification of cognitive impairment by General Practitioners, continues with specialized assessments at Memory and Dementia Centres, and leads, in carefully selected cases, to initiation of anti-amyloid monoclonal antibody therapy. It advocates the rational use of diagnostic tools, including plasma and cerebrospinal fluid biomarkers, advanced neuroimaging (MRI and PET), and genetic profiling (ApoE genotyping), not only to identify eligible patients but also to stratify those requiring alternative care strategies. The paper further defines minimum requirements for the accreditation of prescribing and infusion centres, highlighting the clinical competencies, structural resources, and inter-professional communication protocols necessary to ensure safety and appropriateness. Recognizing both the therapeutic potential and the organizational challenges associated with anti-amyloid monoclonal antibodies, the document aims to guide healthcare policymakers, institutions, and practitioners toward a coordinated reorganization of the diagnostic-therapeutic pathway, ensuring the safe and effective use of these treatments and ultimately improving outcomes and quality of care for individuals with Alzheimer’s disease.
Ključne besede: Alzheimer’s disease, disease-modifying therapies, anti-amyloid monoclonal antibodies, biomarkers, clinical implementation
Objavljeno v RUP: 22.12.2025; Ogledov: 136; Prenosov: 2
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Opis: Background: Suicide underreporting undermines accurate public health assessments and resource allocation for suicide prevention. This study aims at synthesizing evidence on suicide underreporting and to estimate a global underreporting rate. Methods: We conducted a PRISMA-compliant systematic review on suicide underreporting, following a pre-registered protocol. A meta-analytical synthesis was also conducted. Quantitative data from individual studies was extracted to provide an overall global estimate of suicide underreporting (42 studies covering 71 countries out of the initial 770 unique studies, spanning 1900–2021). Most studies used retrospective institutional datasets to estimate underreporting through reclassification of undetermined deaths or comparisons across databases. Demographic and geographic disparities were also examined. Results: The 42 studies selected provided some quantitative data on suicide underreporting for general or specific populations. 14 of these studies provided data to be meta-analyzed. The global suicide underreporting rate was estimated to be 17.9% (95% CI: 10.9–28.1%) with large differences between countries with high and low/very low data quality. In this scenario, the last WHO estimates of suicide deaths – corrected for underreporting – would be more than one million (1,000,638; 95% CI: 859,511–1,293,006) and not 727,000 suicides per year. Underreporting was higher in low- and middle-income countries (LMICs) with incomplete death registration systems, such as India and China (34.9%; 95% CI 20.3–53%), while high-income countries exhibited lower rates (11.5%; 95% CI 6.6–19.3%). Contributing factors included stigma, religiosity, limited forensic resources, and inconsistent use of International Classification of Diseases (ICD) codes. Gender and age disparities were notable; Female suicides and those among younger or older individuals were more likely to be misclassified. Discussion: Addressing suicide underreporting requires improving death registration systems globally, particularly in LMICs. Standardizing ICD usage, improving forensic capacity, and reducing stigma are critical steps to ensure accurate data. Heterogeneity, geographical disparities, temporal biases, and invariance of suicide underreporting for countries with low-quality data demand further corroboration of these findings.
Ključne besede: misclassification, under-reporting, suicide, global burden, global health estimates
Objavljeno v RUP: 18.12.2025; Ogledov: 198; Prenosov: 3
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Opis: Suicidal behaviors among different age groups show epidemiological differences between countries. Specifically, suicide rates for the younger populations appear to be lower in Latin-origin countries (such as Italy, Spain, and Portugal) in comparison to other Western countries (especially Anglo-Saxon countries such as Canada, New Zealand, and Australia). The opposite seems to be true for the older population, suggesting a cross- cultural pattern for suicidal behavior in different ages. The current study replicates a study published in 1999 and compares suicide data between 1990 and 1994 with more recent data from the years 2016 and 2020 to investigate the persistence of previously observed trends. Basically, the recent years’ data confirm the patterns evidenced a quarter of a century ago, and substantially confirm the existence of suicide trends embedded with countries’ cultural factors and traditions. This investigation underlines the importance of incorporating anthropology, sociology, ethnography, and geography while studying culture-related patterns in suicide.
Ključne besede: suicide trends, cultural factors, Western countries, Latin countries, Anglo-Saxon countries
Objavljeno v RUP: 18.12.2025; Ogledov: 142; Prenosov: 2
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Opis: Background and Objectives: The impact of coronavirus disease 2019 (COVID-19) goes beyond the consequences of the infectious disease, especially as the measures taken to prevent the spread of the virus have had a very profound impact on people’s social relationships and everyday lives. Several studies have investigated these effects, but there is a lack of longitudinal studies in Central Europe. Objective: The aim of our study was to observe changes in well-being, loneliness, and suicidal behaviour before, during, and after the COVID-19 pandemic using the same population-based cohort. Materials and Methods: A representative sample of 444 participants completed online questionnaires at four time points: 2019 (wave 0), 2021 (wave 1), 2022 (wave 2), and 2023 (wave 3). Results: The results show significant changes in the levels of well-being and emotional loneliness over these periods. In particular, emotional loneliness increased during the pandemic, followed by a later decrease. Well-being appeared to increase after pandemic-related restrictions diminished but decreased again one year later. No significant changes concerning social loneliness and suicidal ideation were observed. Conclusions: Our study suggests that the COVID-19 pandemic changed the way in which people perceive their well-being and especially their relationships with others. From the data, we can conclude that people’s worldview is now lonelier than before the pandemic.
Ključne besede: COVID-19, loneliness, mental health, well-being, suicide
Objavljeno v RUP: 20.10.2025; Ogledov: 386; Prenosov: 7
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Opis: Background and Objective: During the COVID-19 pandemic, women faced unique employment-related stressors, including higher exposure to unstable working conditions, increased workload changes due to motherhood, and greater risk of infection in certain jobs. This study explores how these factors influence women’s anxiety and subjective well-being, aiming to identify vulnerable groups. Materials and Methods: 230 employed Slovene women, aged from 19 to 64 years (M = 32.60, SD = 10.41), participated in an online survey containing a State-Trait Anxiety Inventory (STAI-6), WHO-5 Well-being Index, and a set of questions regarding their occupation and demographic profile. Hierarchical linear regressions and chi-squared tests were performed. Results: The risk of job or income loss significantly predicted an increase in anxiety levels. However, despite fear of infection, none of the work-related variables predicted a significant decrease in subjective well-being. Women reporting risk of job or income loss are predominantly those with lower education and income, working students, self-employed, or working in the private sector. Conclusions: Employment insecurity is an important contributor to anxiety in women. The findings highlight the need to ensure job security, particularly for women working in precariat working conditions, as their work and economic stability prove to be vulnerable to external economic disturbances.
Ključne besede: COVID-19, women, employment insecurity, anxiety, mental health
Objavljeno v RUP: 08.08.2025; Ogledov: 548; Prenosov: 6
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