| Naslov: | In silico analysis of phages-nanogen interplay : human gastrointestinal tract microbiota dynamics and clinical perspectives |
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| Avtorji: | ID Malat, Ihab (Avtor)
ID Drancourt, Michel (Avtor)
ID Henrissat, B. (Avtor)
ID Grine, Ghiles (Avtor) |
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| Datoteke: |  RAZ_Malat_Ihab_2026.pdf (4,42 MB)
MD5: A2FFE1702354ACAF25C99E2351BFA72C
 https://www.cell.com/heliyon/fulltext/S2405-8440(26)00562-1
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | IAM - Inštitut Andrej Marušič
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| Opis: | Digestive tract nanoarchaea Nanopusillus massiliensis and Candidatus Nanopusillus phoceensis form symbiotic nanogens with residing methanogens Methanobrevibacter oralis and Methanobrevibacter smithii, preventing their translocation by unknown mechanisms. We found that 0.45% of M. oralis YH nanogen genome encoding 18 proteins and 1.12% of M. smithii KB11 nanogen genome encoding 32 proteins were of Caudoviricetes and NAV1 origin. In block encoded glycosyltransferase and S-adenosyl-methionine-dependent methyltransferase confer nanogens (but not methanogens) a capacity in cell wall glycosylation. This hypothetical deduced cell wall glycosylation could prevent pseudomurein endo-isopeptidase-mediated interactions of nanogens with digestive tract virome and further nanogen translocation. These observations renew understanding of methanogen and nanogen-associated physiology and pathologies in the digestive tract and beyond. |
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| Ključne besede: | Archaeal virome, Methanogens, CRISPR-Spacers, Caudoviricetes, Human microbiome, Microbial diversity, Mobile genetic elements, Nanoarchaea, Nanogen, Methanobrevibacter smithii, Methanobrevibacter oralis |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 02.06.2026 |
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| Leto izida: | 2026 |
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| Št. strani: | str. 1-20 |
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| Številčenje: | Vol. 12, iss. 11, [article no.] e45050 |
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| PID: | 20.500.12556/RUP-23156  |
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| UDK: | 579 |
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| ISSN pri članku: | 2405-8440 |
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| DOI: | 10.1016/j.heliyon.2026.e45050 |
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| COBISS.SI-ID: | 282048515 |
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| Datum objave v RUP: | 18.06.2026 |
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| Število ogledov: | 28 |
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| Število prenosov: | 2 |
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| Metapodatki: |    |
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